药剂学翻译.docx

工业药剂学翻译学 院：动物医学院 班 级：药物制剂12-2姓 名：王雪野 学号 指导教师：符华林（教授）5.8AEROSOL DRUG DELIVERY气雾给药Michael Hindle迈克尔·辛德Virginia Commonwealth University, Richmond, VirginiaContents目录5.8.1 Introduction引言5.8.2 Human Respiratory Tract and Aerosol Particle Deposition人类呼吸道和气溶胶粒子沉积5.8.2.1 Human Respiratory Tract人的呼吸道感染5.8.2.2 Mechanisms of Particle Deposition粒子沉积机制5.8.2.3 Pharmacokinetics药代动力学研究5.8.3 Therapeutic Indications for Aerosol Delivery气雾剂治疗的临床适应证5.8.3.1 Current Applications目前的应用5.8.3.2 Future Applications未来的应用5.8.4 Aerosol Drug Delivery Devices气雾剂给药装置5.8.4.1 Introduction引言5.8.4.2 Characteristics of Ideal Delivery Device理想给药装置的特点5.8.5 Metered Dose Inhalers计量吸入器5.8.5.1 Introduction引言5.8.5.2 Metered Dose Inhaler and HFA Reformulation计量吸入器和HFA新配方5.8.5.3 Propellants抛射剂5.8.5.4 Excipients辅料5.8.5.5 Valves阀门系统5.8.5.6 Actuators推动器5.8.5.7 Canisters灌装设备5.8.5.8 Breath Actuation呼吸驱动5.8.5.9 Spacers垫片5.8.5.10 Dose Counters定量杯（室）5.8.6 Dry Powder Inhalers干粉吸入器5.8.6.1 Introduction引言5.8.6.2 Size Reduction and Particle Formation Technologies减小颗粒尺寸与粒子形成技术5.8.6.3 Drug – Lactose Formulations药物-乳剂5.8.6.4 Dry Powder Inhaler Design干粉吸入器的设计5.8.6.5 Exubera吸入用胰岛素-Exubera5.8.7 Nebulizers雾化器5.8.8 Emerging Technologies新兴技术5.8.8.1 Soft Mist Aerosols软雾喷雾剂5.8.8.2 Respimat肺部输药器5.8.8.3 AERx肺部稀释药-AERx5.8.8.4 Mystic肺部药物运输器5.8.8.5 Capillary Aerosol Generator毛细管气雾剂生成器5.8.8.6 Staccato断续式给药5.8.9 Conclusions结论References参考文献5.8.1 INTRODUCTION引言Aerosol drug delivery to the lungs has long been the route of choice for the treatmentof respiratory diseases, including asthma and chronic obstructive airwaydisease. Metered dose inhalers (MDIs), dry powder inhalers (DPIs), and nebulizershave been employed to successfully deliver a wide range of pharmaceuticals principallyto the lungs for local action. However, with their unique characteristics, thelungs have now begun to be targeted as a means of noninvasive delivery of systemicallyactingcompounds, including genes, proteins, peptides, antibiotics,