有机合成中展开剂的选择(国外英语资料).docVIP

有机合成中展开剂的选择 It is common to walk a board when making organic synthesis, and the choice of an agent is critical. Select the appropriate expansion agent is the primary task. The commonly used solvent according to order of increasing polarity probably: Oil ethyl benzene hexane fan: selection of expansion agent mainly is considered based on the samples polarity, solubility and adsorption activity, in TLC, we should know the types of chemical of unknown composition, the attribution of the polarity of the extract from or from the column the mobile phase polarity showed that some samples containing various chemical constituents according to the different polarity can be divided, then for subdivision, substance separation unknown, the agent of choice is a process of exploration, not just from the agent, multi factor comprehensive measure! Solvent: the choice of solvent in chromatography, and the relationship between the separation of components is great. In column chromatography, the solvent (a single agent or a mixed solvent) is customarily called a eluent and is often used in thin or paper chromatography as an expansion agent. Selection of eluent, according to adsorption of the substance to be separated and the agent nature of the combination to be considered in chromatography using polar adsorbent, when isolated material for weakly polar material, generally used in weak polar solvents as eluent; isolated material for strong polar components, shall be the polar solvent as eluent. The polarity of eluent must be reduced if the adsorbent with weaker adsorbent (such as diatomite or talcum powder instead of silica gel) is used for a polar substance. In the operation of the column, the sample is separated, the sample can be added to the method, or a suitable solvent is added to the sample to be dissolved. The solvent for the dissolved sample should be selected with less polarity so that the separated component can be adsorbed. Then the polarity of the solvent is gradually i