两种滇产鼠尾草复方注射液对大鼠在体心肌缺血再灌注损伤的保护作用.pdfVIP

天然产物研究与开发 Nat Prod Res Dev。2007。19：418-421 文章编号：1001-6880(2007)Suppl-0418-04 两种滇产鼠尾草复方注射液对大鼠在体心肌缺血 再灌注损伤的保护作用 苏彦宏 ，段为钢 ，张荣平 ，李惠兰 昆明医学院第一附属医院心； 昆明医学院药理教研室； 昆明医学院药学系，昆明650031 摘 要：与复方丹参注射液(丹参+三七)比较，探讨两种滇产鼠尾草复方注射液，即复方滇丹参(滇丹参+三 七)和复方甘西鼠尾(甘西鼠尾+三七)对大鼠在体心肌缺血再灌注损伤的保护作用。采用在体缺血再灌注模 型。缺血30 min复灌60 min。实验过程中用II导联记录心电图sT段和心率变化，实验后测定心室梗塞面积。 结果：这两种复方鼠尾草注射液能显著降低在体心肌缺血和再灌注过程中sT段抬高水平，轻度加快缺血再灌 注过程心率，相似于复方丹参；这两种鼠尾草复方注射液均能明显减少心室梗塞面积。这两种滇产鼠尾草复方 注射液均有较好的抗心肌缺血再灌注损伤作用，与复方丹参注射液相似。 关键词：心肌缺血再灌注损伤；保护作用；滇丹参；甘西鼠尾；三七 中图分类号：R284．2 文献标识码：A Two Compounded Injections Made from Herbal Drugs Native to Yunnan China Protecting Myocardium from Ischemia／Reperfusion Injury in Rats／n vivo SU Yan．hong ，DUAN Wei．gang ，ZHANG Rong-ping ，LI Hui-lan ’ The Medicinal Department ofCardia．池 First Hospital Affiliated to Kunming Medical College；2Department of Pharmacology，Kunming Medical College； Faculty ofPhamacy，Kunming Medical College，Kunming 650031，China Abstract：In order to find out the eardio protection induced by the compounded injections made from SY+PN or SP+ PN。during isehemia／repoffusion in rats in vivo，compared with injection made from SM+PN，and to find out whether SY and SP Can be used 88 candidates of SM against eardio isehemia／poffusion injury or not，rats’artery of left anterior de· scending(LAD)was ligated for 30 min，then let it loose for 60 min；electrocardiogram(ECG)was recorded to check heart rate and ST segment during experiment and ventricle isehemieal area was calculated after reporfusion．The injee- fions of SY+PN and SP+PN alleviated isehemia area．not less powerful than that of SM+PN；Two injections WSS able to~cken heart rate and alleviate ST·segment．as compou