代谢综合征患者胰岛素敏感性和β细胞功能研究_洪洁.pdf

Vol.22 No.4 2002 Acta Universitatis Medicinalis Secondae Shanghai ·327 · 　　【】　0258-5898(2002)04-0327-04 β 1 2 1 2 1 1 　 , 　 , 　　, 　 , 　, 　 (1., 　200025;2.) 【　】　目的 、、(IGT )、 IGT 2 (T2DM)β 。 　方法 Bergman (FSIGT) (S )、(S ), I G FSIGT (Ip-b), β 。 　结果 1.、S , G IGT、IGT T2 DM , S 。 2. S 5 。 3. G I , 、IGT Ip-b, IGT T2 DM Ip-b 。 　结论 β , 、IGT , T2 DM IGT , β , , 。 【】　;　β ;　;　 【】　R589 .1;　R 446.11 　　　　【】　A Study on Insulin Sensitivity and Early β Cells Function in Patients with Metabolic Syndrome HONG Jie, Gong an_chun, NING Guang, et al (Dep artment of Endocrinology , Ruij in Hosp ital, SSM U, Shanghai 　200025, China ) 【Abstract】　Obj ective 　To study insulin sensitivity and early islet β cells function in simple obe- sity, simple hypertension, obesity w ith impaired glucose tolerance(IGT ), hypertension with IGT and obe- sity with type 2 diabetes (T2DM ).　M ethods 　Insulin sensitivity index (SI ), and glucose effectiveness (SG )w ere assessed by the reduced sample number of the Bergmans minimal model method with the fre- uently sampled intravenous glucose tolerance (FSIGT )test in the subjects of each target group.Mean- w hile the early islet β cells function w as also evaluated by the follow ing two parameters:Ip-b stands for the difference betw een the peak insulin value and the basal insulin value after glucose injection in FSIGT .　 Results 　1.There was no signifi