年产7.2吨头孢三嗪酸工艺设计.docVIP

摘要 优化项目共有4个课题：7-ACT的制备；头孢三嗪酸的制备；成盐精制；结晶优化。本次设计题目为是年产7.2吨头孢三嗪酸工艺设计。 在此次设计过程中，针对各个反应各个物料的性质和反应特点进行了简要的研究并设计出生产流程。通过物料衡算计算该生产，过程包括：反应工段；萃取工段；脱色工段；结晶工段；离心过滤工段。成品为头孢三嗪酸晶体，目标产率为90%左右。 此外，依据任务书中的安排，还进行了关键设备的设计，即反应釜的工艺设计。设计包括构成反应釜装置的五大部分：釜体几何尺寸，搅拌装置，传动装置，传热装置，轴封。在头孢三嗪酸的生产过程中，其特点为药物中间体物性参数难以获得，反应介质粘度较低等。对于以上特点，我们在设计过程中通过基团贡献法估算反应物热力学参数来进行能量衡算；针对粘度较低，通过在反应釜内设置挡板等使反应顺利进行。 本次设计中，还讨论了生产过程中所需要的其他附属设备的选型。并且绘制了带控制点的工艺流程图，车间布置图和反应釜的剖面图。 关键词：头孢三嗪酸；工艺设计；反应釜  Abstract Optimization of the project consists of 4 topics: 7-ACT preparation; preparation of three hydrochloride acid; salt refining crystallization optimization. This design topic is an annual output of 7.2 tons of three hydrochloride acid process design. In the design process, according to the characteristics of each reaction properties and reactions of various materials are briefly studied and designed the production process. Through the material balance calculation of the production process, including: reaction section; extraction process; bleaching section; crystallization process; centrifugal filtration process. The finished product is of three hydrochloride acid crystal, the target yield is about 90%. In addition, according to the task book arrangement, also carried out the design of key equipment, i.e. process design of reactor. The design consists of five parts: the kettle reactor size, stirring device, transmission device, transfer device, seal. In the production process of three hydrochloride acid, characterized by intermediate properties of drugs are difficult to obtain, reaction medium and low viscosity. For the above characteristics, we by group contribution method in the design process to the energy balance to estimate the reaction thermodynamic parameters; the lower viscosity, the baffle is arranged in the reaction kettle to react smoothly. In this design, selection and other ancillary equipment required in the production process are also discussed. The process flow chart with control points, profile plant layout