糖尿病肾病患者血循环激肽释放酶1水平及其临床意义的研究.pdfVIP

Blood circulating level of kallikrein 1 and its significance in patients with diabetic nephropathy ABSTRACT Objective Although patients with diabetic nephropathy(DN) strict metabolic control and strict treatment of hypertension, DN progress maintained a serious clinical problem. More and more evidence that the DN is a multi-factor disease, it’s pathological mechanism is unclear today. Recent studies have confirmed that kallikrein-kinin system(KKS) plays an important role in the DN progress.KLK1 play in the diabetic state in addition to its effect in renal hemodynamic activity than the product through its regulation of glomerular mesangial cells, renal tubular epithelial proliferation and participate in the progress of DN. Therefore, to explore KLK1 in DN and its clinical significance in research of mechanisms of DN progress to provide a basis to treatment the disease.In this study we determine blood level of KLK1 in patients with DN to analysis it’s change on different stages of DN and its correlation with UAER,HbA1c,PP and Cr in DN for clinic implication. Methods According to DN clinic stages,divided 64 newly diagnosed type 2 diabetes mellitus(T2DM) patients who enrolled in Guangxi Zhuang Autonomous Region Nanxishan Hospital and received system treatment during Mar.2009 to Dec.2009 into three groups(normal proteinuria group,micro proteinuria group and large proteinuria group). Normal proteinuria group : 23 males and 9 females, average age was 54(43-65)years old, UAER level range from 0 μg/min to 20 μg/min; 3 Micro proteinuria group:12 males and 8 females, average age was 57(45-69)years old,UAER level range from 20 μg/min to 200 μg/min; Large proteinuria group:4 males and 8 females, average age was 59(50-68)years old, UAER level higher than 200 μg/min. UAER is determined by immunoturbidimetry continuing 3 days(only morning uri