肠易激综合征的病因及发病机制_成金玲.pdfVIP

1370 2009 5 15 9 M ed ical Recap itu late, M ay 2009, Vo.l 15, No. 9 1 2 成金玲 ( ) , 丰义宽 ( ) ( 1. , 261042; 2. , 261041) : R574. 4 : A : 1006-2084 ( 2009 ) 09-1370-03 : 肠易激综合征( IBS) 是一种生物-心理-社会病症, 其病因及发病机制仍未完全明了主 , - 流 点认为是由于遗传( 基因) 和环境 ( 如社会压力) 等因素造成中枢神经和肠神经丛的调节失 - 衡, 从而导致胃肠动力和内脏感觉异常, 引起症状IBS是一种多因素引起的功能性疾病, 目前对 其病因和发病机制的研究已从多方面开展, 并提出不同 点, 如遗传因素胃肠运动异常内脏高 , 敏感性炎症和免疫因素消化道激素及心理因素等 - : 肠易激综合征; 发病机制; 发病因素 IBS 1 Etiological Factor and Pathogen ic M echanism of Irritable Bowel Syndrom e CHEN G Jin-ling , , 2 FEN G Yi-kuan . ( 1. Depar tm ent of Gastroenterology, W efiang M e ical College, Weif ang 261042, China; , 2. Dep artm ent of Gastroenterology, Aff iliate Weif angP eop lesH osp ital of W efiangM e icalCollege, Weif ang 261041, China) - Abstract: Irritab le bow el yndrom e i a b io log ical-p ychological- ocial d i ea e, and it etiopathogen i- [ 4] IBS i and pathogen e i are till not fu lly under tood. Ma in tream view i that genetic ( gene) and env iron- m en talfactor ( u ch a ocia l pre u re) re u lt in th e d i balance of cen tral n ervou and in te tinal plexu , and th en lead to abnorm ality of ga troin te tinalm otility and vi ceral en e, w h ich u ltmi ately cau e ym p- tom . Irritab le bow el yndrom e i a fun ction al di ea e, wh ich i cau ed by om e factor . A t p re en t, the re- earch abou t it etiopathogen i i and pathogen e i ha been carried out in m any w ay , and om