可益能对胰岛素抵抗的作用.pptVIP

Having seen this data, would you consider using L-carnitine treatment more routinely in your practice? 看到这些数据，您会考虑在临床实践中常规使用可益能治疗吗 * You have no doubt experience with Metformin alone or in combination with Glitazones in the treatment of Insulin Resistance (IR). Have you ever experienced L-Carnitine, an endogenous substance that plays a key role in intermediate metabolism? 毫无疑问，您有过单独使用二甲双胍或联合格列酮治疗胰岛素抵抗的经历，您曾经用过左卡尼汀吗，是一种在中间产物代谢中起重要作用的内源性物质 The team of De Gaetano utilized a pharmacokinetic technique Minimal Modelling to evaluate the efficacy of Carnitine on glucose metabolism in healthy subjects. De Gaetano 团队利用药代动力学的最小模型来评价了健康人中可益能对糖代谢的作用 * Glucose disposal The results showed that in the first 90 minutes, Carnitine seems to increase overall glucose elimination from plasma 结果显示在前90分钟，卡尼汀能够增加总体的血浆葡萄糖的清除 * These data open a new scenario: Carnitine, by interfering with glucose metabolism, may have a role in the therapy of Insulin Resistant patients. This suggestion was confirmed by Capaldo in a small group of IR patients with T2D on standard therapy. The euglycemic hyperinsulinemic clamp technique showed that … 这些数据打开了一个新的方案：卡尼汀，通过干预葡萄糖代谢，可能起到治疗胰岛素抵抗的作用。这个建议被Capaido在一个给予标准治疗的一小组有胰岛素抵抗的2型糖尿病患者的中证实，胰岛素钳夹技术表明、、、 * the acute treatment with Carnitine induced a significant increase in whole-body glucose utilization. 及时的可益能治疗引起显著的全身葡萄糖利用的增加 * Therefore, the possibility that carnitine could affect IR seems to be real. 因此，卡尼汀对胰岛素抵抗的作用是确定的 Nevertheless, to complete the preliminary puzzle, we need one more element. The team of Mingrone evaluated the effect of Carnitine not only on glucose disposal, but also on glucose oxidation. 然而，为了完全解决最初的疑惑，我们还需要另外一个要素，Migrone团队不仅仅评估了葡萄糖清除的作用，也评估了葡萄糖氧化的作用 胰岛素和前列腺素等与上述激素作用相反，可抑制脂动员，称为抗脂解激素(antilipolytic hormones)。 * euglycemic hyperinsulinemic clamp： 正常血糖高胰岛素钳夹技术：作为评价胰岛素敏感性的金字标准，这个钳夹技术要求在一个胳膊的静脉注入恒量的胰岛素。 通过在另一个胳膊静脉注入不同量的葡萄糖，血清葡萄糖被固定在正常空腹水平。通过多次采血，监测血糖水平，这样可以维持稳定的“空腹”水平。（理论上，静脉注射胰岛素能够完全抑制肝糖的产生，而且对检测目标组织对胰岛素的敏感性不产生影响）。胰岛素抵抗程度应该与实验过程中目标组织摄取的葡萄糖成反比