BMI与胆道肿瘤关系.pdfVIP

/oncotarget/ Oncotarget, Advance Publications 2016 The association between BMI and gallbladder cancer risk: a meta-analysis 1,2 1 1 2 1 Zhan-Ming Li , Zhao-Xia Wu , Bing Han , Yu-Qin Mao , Hui-Ling Chen , San-Feng 1 1 1 Han , Jing-Lin Xia , Li-Shun Wang 1 Institute of Biomedical Sciences, Minhang hospital, Fudan University, Shanghai, P.R. China 2 Ruijin hospital, Shanghai Jiao-tong University School of Medicine, Shanghai, P.R. China Correspondence to: Li-Shun Wang, email: lishunwang@ Jing-Lin Xia, email: xiajinglin@ Keywords: BMI, gallbladder cancer, meta-analysis, overweight, obese Received: October 22, 2015 Accepted: May 11, 2016 Published: May 27, 2016 ABSTRACT Obesity is a known cause of gallstone formation and gallstones increases the risk of gallbladder cancer (GBC), but the relation of body mass index (BMI) to GBC remains incompletely understood. To help elucidate the role of obesity in GBC, we performed a meta-analysis of the relationship between BMI and GBC risk. PUBMED and EMBASE databases were searched up to April 17, 2016. Fifteen articles with 5902 cases were identified. Random-effects models and dose-response meta-analyses were used to pool study results. Compared to normal weight, the pooled relative risks (RRs) and the corresponding 95% confidence intervals (CI) of GBC for overweight and obesity is 1.10 (0.98-1.23) and 1.58 (1.43-1.75) respectively. The RRs and 95% CI of overweight and obesity in man are 0.98 (0.90-1.08) and 1.43 (1.19-1.71), while the corresponding RRs in woman are 1.29 (1.08