揭开美国顶尖生物医学实验室成功的法宝(国外英文资料).docVIP

揭开美国顶尖生物医学实验室成功的法宝(国外英文资料) Uncover the magic of success in Americas top biomedical Labs In March 2005, I had the honor of joining the Harvard Medical School, Brigham and Women Elledge (s Hospital) Stephen Elledge laboratory, and worked directly for six years under the direct leadership of prof.. Stephen Elledge (later known as Steve) is a genius scientist in the field of Biomedical Science in the United States. He graduated from the Department of biology at Massachusetts Institute of Technology (MIT) and worked as a postdoctoral fellow at the Department of Biochemistry at the Stanford University. In 1989, he became an assistant professor of Biochemistry at the Baylor College of Medicine (Baylor Medical College). Just a few years later, Howard was elected to the Hughes Institute for medical research in 1993 (HHMI, Investigator). In 2003, he was elected Fellow of the American Academy of sciences. In early 2003, he was named Professor of genetics at the Brigham and womens Hospital of Harvard Medical School in the United States as a tenured professor. He is in many research areas, such as cell cycle regulation, DNA damage response mechanism, tumor cell biology, ubiquitin ligase composition and regulation, the new bio technology development and utilization as well as the virus infection mechanism has outstanding contribution. He found a direct downstream target of tumor suppressor gene TP53 P21, DNA ATR, ATM after injury and activation of protein kinase CHK1 and downstream CHK2 signaling pathway found in him, he found that the tumor suppressor gene REST and PTPN12, revealing the F-box ubiquitin ligase family, optimization of the yeast two hybrid system (Yeast two, hybrid system) the whole level of proteomics analysis of GPS protein stability Magic DNA vector high-throughput conversion system, and the first small hairpin RNA interference library and Gregory Hannon (shRNA library). He has published more than 20 articles in the Cell, Nature and Science magazines in the 50