20100515Shanghai血脂治疗新进展中文江晨恩.pptx

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20100515Shanghai血脂治疗新进展中文江晨恩.pptx

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20100515Shanghai血脂治疗新进展中文江晨恩

血脂治療新進展;Outlines;;Global Cardiovascular Burden in 1990;CHD mortality trends in men aged 35-44 in Japan, South Korea, and Taiwan Korea;中國心臟病死亡人數;;Explaining the Decline in CHD Mortality;Decrease in CHD mortality in US 1980-2000;血脂控制+血脂治5.1%;Nikolai Nikolajewitsch Anitschkow;胆固醇-FED RABBIT;Outlines;;;LDL-C level in hospitalized CHD pts 136,905 pts in GWTG database, mean LDL-C=105;;;;hs-CRP level and risk;;为什么考虑他汀治疗低LDL-C, 高hs CRP的病人;;;;;;Outlines;;;;;;;-17%;Percent of patients with;44%;;JUPITER Primary Endpoint – Subgroup Analysis I;7,009;Proportional reduction in;Relationship Between Changes in LDL-C Levels and CHD Risk;Relative Risk Reduction (%);Lipid management in the prevention of stroke;;;;;Are statins effective in the elderly?;IHD Mortality and Usual Total Cholesterol (61 trials, 892,337 pts, 11,600,000 pt-yr);Stroke Mortality and Usual Total Cholesterol (61 trials, 892,337 pts, 11,600,000 pt-yr);Cork;Prosper;Lancet 2002; 360: 1623–30.;;-49;-0.22;;;;;Stroke sub-analysis;Lancet 2002; 360: 1623–30.;SPARCL;SPARCL: Main results;SPARCL: Post Hoc Analysis;Hemorrhagic stroke in the SPARCL study;Coronary and CV events;;;;;Outlines;;;Lancet, Published Online February 17, 2010;Risk of diabetes associated with age;Atorvastatin Causes Insulin Resistance and;Atorvastatin Causes Insulin Resistance and;No clear difference between statins in terms of;;;Outlines; 40-80 (neonate 30-70) 130 mg/dl J Am Coll Cardiol 2004;43:2142;LDL threshold 极限值;Change in % Stenosis/year Change in MLD (mm/year);Change in percent;LDL-C; LDL-C achieved mg/dL (mmol/L) Exp Opin Emerg Drugs 2004;9(2):269–279, N Engl J Med 2005;352:1425–1435. JAMA 2005;294:2437; Lancet 2006;368:1155;10 5 0;;Outlines;30-;; Effect of urgent treatment of TIA and minor stroke on early recurrent stroke (EXPRESS);Statin;Risk of recurrent stroke;;Impact of Statin Use within one month after CABG;Mortality;Long-Term Follow-up of the WOSCOPS WOSCOPS研究的长期随访;;Outlines;Lowering LDL; Sequence Variations in PCSK