慢性肾脏病患者脑钠肽水平变化及及心功能相关性研究.docVIP

慢性肾脏病患者脑钠肽水平变化及与心功能相关性研究 呼伦贝尔市海拉尔区人民医院 张淑艳 萨如拉 刘家宇，呼伦贝尔 021008 【摘要】　目的观察慢性肾脏病()患者不同时期血浆脑钠肽水平的变化,评价其患者高血容量负荷心功能不全。方法根据肾小球滤过率()将例患者分为4组-Ⅰ、Ⅱ期组-Ⅲ期组-Ⅳ期组-Ⅴ期组同时设对照组例。结果1) CKD-Ⅰ、Ⅱ期-Ⅲ期-Ⅳ期-Ⅴ期血浆水平均较对照组高有统计学意义(0.01)；CKD患者BNP水平各组间均有统计学差异(0.01)，且随而逐渐增高。2)血浆水平与左心室射血分数呈负相关与)在例患者中共例左心室扩大者其血浆水平为(～) ng/L，中位数为/L，显著高于的例患者的水平为(～) ng/L，中位数为/L，差异有统计学意义(0.001)。结论患者血浆水平随着肾功能的逐渐增高是功能容量负荷的敏感指标。 【关键词】　脑钠肽慢性肾脏病心功能Changes of brain natriuretic peptide level in patients with chronic kidney disease and its relationship with cardiac function ZHANG shu-yan SA ru-la LIU jia-yu , Peoples Hospital of Hailar District ,Hulun Buir 021008 ,China. Abstract Objective: To observe the changes of plasma brain natriuretic peptide levels in patients with chronic kidney disease (CKD) at different stages, and to evaluate the correlation between the high blood volume load and cardiac insufficiency in patients with chronic kidney disease (CKD). Methods: according to the glomerular filtration rate (eGFR) of 200 CKD patients were divided into 4 groups, CKD- stage group, CKD- stage group, CKD- stage group and CKD- stage group, while 30 cases in the control group. Results: 1) CKD- I, II, III and IV CKD- CKD- stage, CKD- stage patients with plasma levels of BNP were significantly higher than the control group, and there was statistical significance (P0.01); and there was significant difference in the level of BNP in patients with CKD group (P0.01), and gradually increased with the decline of eGFR. 2) Spearman correlation analysis showed that the plasma BNP levels were negatively correlated with glomerular filtration rate, left ventricular ejection fraction, and hemoglobin, and the mean arterial pressure was not significantly correlated with the mean arterial pressure in all patients with CKD. 3) in 200 CKD patients, 84 cases of left ventricular enlargement, the plasma level of BNP was (631 ~ 32500) ng/L, median 9220.80ng/L, significantly higher than the normal LVDd of 116 patients with BNP level (39 ~ 6850) ng/L