氧化纤维素可吸性止血纱布在胸腹部微创手术中应用.docVIP

氧化纤维素可吸性止血纱布在胸腹部微创手术中应用[摘要] 目的：观察氧化纤维素可吸性止血纱布（捷力特）在胸、腹部微创手术中的止血效果及评价其安全性。方法：选择本院2011年3～7月利用氧化纤维素可吸性止血纱布（捷力特）对进行胸、腹腔镜手术出血的创面进行止血的85例患者进行统计学分析，通过对创面凝血时间的观察、对组织的刺激和急性毒性反应等，考察其止血效果和评价其安全性。结果：氧化纤维素可吸性止血纱布（捷力特）能明显缩短创面出血时间，无急性毒性、过敏性和刺激性，植入后吸收良好。结论：氧化纤维素可吸性止血纱布（捷力特）是安全、良好的外科止血材料 [关键词] 氧化纤维素可吸性止血纱布（捷力特）；止血效果；安全性；临床应用 [中图分类号] R619 [文献标识码] C [文章编号] 1674-4721（2011）11（c）-182-02 The application of resorbable oxidized cellulose in the surgical operation in chest and abdomen minimally invasive surgery FANG Wanqiang, FANG Ziwen, RUAN Lingling Department of 1st surgery, the Center Hospital of Kaiping City, Guangdong Province, Kaiping 529300, China [Abstract] Objective: To observe and evaluate the stanch effects and safety of Gelitacel (resorbable oxidized cellulose) in the surgical operation in chest and abdomen minimally invasive surgery. Methods：In the period of March to July in 2011, prospective and retrospective (control group) investigation was carried out to assess the effectiveness of Gelitacel (resorbable oxidized cellulose) to reduce blood-loss in 85 patients with benign surgical operation in chest and abdomen minimally invasive surgery. The stanch effects and safety of this material was investigated through its effects on blood coagulation time, skin and acute toxicity test and stimulus to body. Results: The resorbable oxidized cellulose could shorten wound bleeding time obviously and its influences to blood coagulation time, stimulation and hypersensitiveness to skin and acute toxicity to animals were not found in this study. Conclusion: The Gelitacel (resorbable oxidized cellulose) is a safe and effective styptic material in surgery． [Key words] Gelitacel (Resorbable oxidized cellulose); Effection; Safety; Clinical application 止血是各种手术及战伤急救的重要环节，虽然外科技术发展很快，止血技术也有明显进步，但还不能满足现代外科的需要[1]。微创手术对创面止血的技术要求会更高，氧化纤维素（oxidizedcellulose，OC，也称6-羧基纤维素，1）为纤维素的衍生物，有良好的生物相容性、生物可降解性并且无毒，目前已被用于多种行业，包括在医疗领域中，作为医用可吸收纱布[2]。而本文就是以此为目的，对本院2011年3～7月利用氧化纤维素可吸性止血纱布（捷力特）对进行胸、腹腔