氧化苦参碱生物黏附缓释片在Beagle犬体内的药动学.pdfVIP

.oft 久，学报 Joumal of China Phannaceulical Universily 2∞8.39(6) :523 -525 523 氧化苦参碱生物蒙古附缓释片在 Beagle 犬体内的药动学 尹莉芳1 ，王广基2 · ， 张陆勇3 ，赵存捷\周建平 (中国药科大学 1 药剂学教研室;2 药物代谢动力学重点实验i;1新药筛选中心，南京21仪览防) 摘 要 目的:考察氧化苦参~生物秘附缓铮片在 h锦Je 犬体内的药动学过程。 方法:建立民-MS 法同时测定Besgle 欠血浆中的氧化苦+.4l及其代谢产物苦参碱。 采用 BAPP 2.3 程序估算火nm市售普通胶囊(参比例剂)和氯化苦参碱生 物秘附靠在锋片(受试制剂)后的药动学参疆生。 结果:氯化苦4t~血药浓度·时间曲线符合双室模型特征。 受试制剂的生物利 用度为 11 0.9.且c_降低、t_延长.具有後传效呆。 n周受试制弗l后测得苦参碱的量为.u.用参比帝JM后测得量的9O. 5Q岛。 结论:氯化苦参~生物#附毒草锋片与市i!普通股.相比，生物利用皮等效，具有明显的靠在绎效果。 关键诵 氧化苦参~;苦参.ll;生物量占附缓李片;药动学 中国分类号 R969 . 1 文献标识码 A 文章编号 l创)() -5048(筑l(8)06 -0523 -03 Pharmacokinetics of oxymatrine bioadhesive sustained-release tablets in Beagle dogs 3 l l YIN Li-fangl , WANG Guang才i2 • , ZHANG Lu-yong , ZHAO Cun-jie , ZHOU Jian-ping 1Je，阳tmenl 01 p阳， m刷刷刷;2 Ker Laborω， ory of Drug Metαbofum Pham皿co/úne!ÏC; J N阳岛咯， Screen吨 Cenrer. China Phorrn.aaUlícai UniverJÎSr, N.叫ing 211贼)9. China Abstract Aim: To study phannacokinetics of oxymatrine bioadhesive sustained-release tablets in ßeagle dogs. Methods : LC-MS melhod wω 创tablished 10 detecI ox归natrine and malrine in plasma of Beagle dogs simul- 阳eously. BAPP 2. 3 was applied to analyze the experimental data after Beagle dogs we陀 given commercial tab- lets as reference and oxymatrine bioadhesive 8ustained-release tablets ω 阳t. Resul1s : Dis阳西ition of oxymatrine in Beagle dogs fined with two-compartment model. The bíoavailability of oxymatrine bioadhesive 5ustained-release tablelS wω110. 9% ,c was observed 10 be decreased and t was prolonged. The detected quantity of matrine after dosing of the test p陀paralion to Beagle dogs was 90.5% of thal after the 陀ference preparation. Conclusion: Oxymalrine bioadhesive 时Jets had sustained-release prope向· Key words oxymatrine; matrin