p-PI3K p85α 南京医科大学(英文版).pdfVIP

Experimental Gerontology 46 (2011) 1031–1036 Contents lists available at SciVerse ScienceDirect Experimental Gerontology journal homepage: www. elsevier. com/ locate/expgero Short report Prophylactic lithium alleviates postoperative cognition impairment by ☆ phosphorylating hippocampal glycogen synthase kinase-3β (Ser9) in aged rats LongDe Zhao a, 1, FuZhou Wang b, 1, Bo Gui a, FuZhou Hua a, YanNing Qian a,⁎ a Department of Anesthesiology, The First Affi liated Hospital to Nanjing Medical University, Nanjing 210029, China b Department of Anesthesiology and Critical Care Medicine, Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University, Nanjing 210004, China a r t i c l e i n f o a b s t r a c t Article history: Postoperative cognition impairment is a perishing complication in elderly patients undergone surgeries. Lithium Received 5 June 2011 is widely used in psychiatric patients for its role in neuronal protection, whereas whether or not it could Received in revised form 24 August 2011 attenuate surgery-associated postoperative cognition dysfunction used prophylactically is not well defined. Accepted 6 September 2011 After approval by the Institutional Animal Care and Use Committee, 48 male Sprague–Dawley rats aged Available online 16 September 2011 18 months old were randomly divided into three groups with 1