细胞生物学3第2章细胞组织微环境.pdfVIP

S. Waldman/B. Amsden CHEE 340 Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology. 2011. Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology. 2011. Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology. 2011. Dvir, Tal, et al. Nanotechnological strategies for engineering complex tissues. Nature Nanotechnology. 2011. 肿瘤细胞从来不是孤立存在，而是作为 “肿瘤器官”存在与发展 Invasive Cancer In SITU Cancer ECM Fibroblasts, adipocytes BloodVessel Leukocytes, macrophages,etc Source: Weinberg, Sci Am (1996) endothelial Cells, myoepithelial cells Proteases Tumor Cell-Microenvironment Interactions OR Tumors Are More Than Just Cancer Cells 肿瘤七大基本特性都与其微环境密切相关 Mantovani A Nature 457, 36-37 (2009) Metastasis is the cause of 90% of deaths from solid tumors 肿瘤演进过程的每一环节都与其微环境息息相关 肿瘤转移的主要步骤 Characteristic features of metastasis – steps in a cascade - loss of cellular adhesion - increased motility and invasiveness - entry and survival in the circulation - exit into new tissue - eventual colonization of a distant site Apical Surface Tight junction Adherens junction Desmosome Gap junction focal adhesions Basolateral Surface Altered Cell Morphology Breakdown of Intercellular