甲氯芬酯联合纳洛酮治疗急性酒精中毒昏迷临床观察.doc

甲氯芬酯联合纳洛酮治疗急性酒精中毒昏迷临床观察[摘要] 目的 初步探讨甲氯芬酯联合纳洛酮在急性酒精中毒昏迷治疗中的作用。方法 将133例符合急性酒精中毒昏迷标准的患者随机分为两组。对照组68例，给予洗胃、补液和纳洛酮持续静脉点滴。治疗组65例，在对照组治疗方法基础上加用甲氯芬酯。观察两组患者心率、收缩压、昏迷时间和纳洛酮用量的差异。结果 两组患者治疗后心率下降(P0.05)。结论 在纳洛酮治疗酒精中毒昏迷中合用甲氯芬酯比单药使用有更好的促醒作用且对心率、收缩压无明显影响 [关键词] 甲氯芬酯； 急性酒精中毒； 治疗 [中图分类号] R595.9 [文献标识码] A [文章编号] 1005-0515（2011）-12-032-01 Curative Effect of Meclofenoxate Hydrochloride and Naloxone in the Treatment of Coma Caused by Acute Alcoholic Intoxication Wang Jia (Department of Emergency,the First Central Hospital of Tianjin,Tianjin 300192,China) [Abstract] Objective To investigate into the curative effect of Meclofenoxate Hydrochloride and Naloxone Hydrochloride in the treatment of the coma caused by acute alcoholic intoxication. Methods 133 samples collected from the patients who suffered from the coma caused by acute alcoholic intoxication were randomly divided into two groups.68 patients of the control group got thoroughly gastric lavage and were used Naloxone Hydrochloride for injection, while 65 patients,as the treatment group,were used Meclofenoxate Hydrochloride before the same treatment method of the former group is adpted to them.We compared the curative effect of the two groups by the improvement of heart rate, systolic pressure,the length of time for recovering consciousness and the total dose of Naloxone Hydrochloride used in the treatment procedure. Results All patients’ heart rate decreased (P0.05).Conclusion In the treatment of the coma caused by acute alcoholic intoxication, Meclofenoxate Hydrochloride and Naloxone Hydrochloride have a better clinical curative effect than Naloxone Hydrochloride used alone and have no significant effects in heart rate and systolic pressure. [Key words] Meclofenoxate Hydrochloride; Acute alcoholic intoxication; Treatment 急性酒精中毒系由一次饮入过量酒精或酒类饮料引起的中枢神经系统由兴奋转为抑制的状态，严重者出现昏迷、呼吸抑制及休克[1]。纳洛酮在酒精中毒治疗中具有重要地位。但纳洛酮静脉注射起效后持续时间短，仅持续30-60分钟；半衰期短，血浆t1/240-55分钟[2]。治疗中需要多次给药，潜在提高了其毒副作用发生的可能性。本研究旨在观察急性酒精中毒昏迷患者在接受传统纳洛酮等治疗基础上应用甲氯