阿托伐他汀联合胺碘酮治疗阵发性心房颤动疗效观察.docVIP

阿托伐他汀联合胺碘酮治疗阵发性心房颤动疗效观察【中图分类号】R541.7 【文献标识码】A 【文章编号】1672－3783(2011)12－0047－01 【摘要】目的：探讨阿托伐他汀联合胺碘酮治疗阵发性心房颤动实际临床疗效。方法：临床统计了54例阵发性心房颤动患者，随机分为治疗组和对照组各27例，对照组行胺碘酮治疗，治疗组行阿托伐他汀联合胺碘酮治疗，随访1年，观察统计两组患者的实际疗效。结果：治疗组27例患者中，有效21例，无效6例，复发率为22.22%；对照组27例患者中，有效16例，无效11例，复发率为40.74%。结论：阿托伐他汀联合胺碘酮治疗阵发性心房颤动疗效显著，值得临床推广应用 【关键词】阿托伐他汀；胺碘酮；阵发性心房颤动；疗效 Effect of Atorvastatin Combined with amiodarone for treatment of paroxysmal atrial fibrillation curative effect observation 【Abstract】Objective: To investigate the effects of Atorvastatin Combined with amiodarone in the treatment of paroxysmal atrial fibrillation in actual clinical curative effect. Methods: clinical survey of 54 cases of paroxysmal atrial fibrillation patients, were randomly divided into treatment group and control group with 27 cases in each group, the control group treated with amiodarone, treatment group was treated with Atorvastatin Combined with amiodarone treatment, follow-up of 1 years, on the observation and statistics of the actual effect of two groups of patients. Results: in the treatment group of 27 cases, effective in 21 cases, 6 cases are invalid, the recurrence rate was 22.22%; the control group 27 cases, effective in 16 cases, 11 cases are invalid, the recurrence rate was 40.74%. Conclusion: effect of Atorvastatin Combined with amiodarone for treatment of paroxysmal atrial fibrillation a significant effect, is worth the clinical promoted application. 【Key words】atorvastatin; amiodarone; paroxysmal atrial fibrillation; curative effect 阵发性心房颤动在临床心律失常中十分常见，并且随着年龄的增加，阵发性心房颤动的患病率也呈增加趋势。另外，阵发性心房颤动还是心力衰竭的常见诱因，常常引起栓塞并发症。对阵发性心房颤动的传统治疗，常常采用胺碘酮进行预防，也取得了一定的疗效。探讨临床上阿托伐他汀联合胺碘酮治疗阵发性心房颤动的实际疗效，为今后阵发性心房颤动的治疗提供参考，帮助阵发性心房颤动患者提高生活质量 1 资料与方法 1.1 临床资料:临床统计了54例阵发性心房颤动患者，其中男性患者31例，女性患者23例，年龄从51~69岁，平均年龄为63.2岁。所有患者均经过普通心电图、询问病史、动态心电图、体格检查、生化检查、胸部X线等检查。所有患者心房颤动发作频率每月在2次以上，临床症状主要有胸闷、心悸、头昏，具备应用他汀类药物的指征，排除球囊扩张的瓣膜性心脏病、严重肝肾功能障碍、甲状腺疾病、服用三环抗抑郁药者、妊娠者等 1.2 治疗方法:将临床统计的54例阵发性心房颤动患者随机分为治疗组和对照组，治疗组27例，对照组27例。对照组采用胺碘酮治疗，第一周给予每日600