肝纤维化瞬时弹性成像和生物标志物 Castera_APT2011.pdfVIP

Alimentary Pharmacology and Therapeutics Transient elastography and biomarkers for liver fibrosis assessment and follow-up of inactive hepatitis B carriers ´ , , § L. Castera* , P.-H. Bernard , B. Le Bail , J. Foucher* , P. Trimoulet , W. Merrouche*, P. Couzigou* ´ V. de Ledinghen* ´ ´ *Service d’Hepato-Gastroenterologie, SUMMARY ˆ ´ ˆ Hopital Haut-Leveque, Centre Hospit- alier Universitaire (C.H.U.) Bordeaux, Background Pessac, France. ´ ´ Non invasive methods for fibrosis evaluation remain to be validated longi- Service d’Hepato-Gastroenterologie, ˆ ´ Hopital St-Andre, C.H.U. Bordeaux, tudinally in hepatitis B. Bordeaux, France. Service d’Anatomo-Pathologie, Aim ˆ Hopital Pellegrin, C.H.U. Bordeaux, Bordeaux, France. To evaluate longitudinally transient elastography (TE) and biomarkers for § ˆ liver fibrosis assessment and follow-up of hepatitis B virus (HBV) inactive Laboratoire de Virologie, Hopital Pellegrin, C.H.U. Bordeaux, Bordeaux, carriers. France. Methods Correspondence to: Three hundred and twenty-nine consecutive HBeAg-negative HBV patients ´ ´ (201 inactive carriers) who underwent TE, Fibrotest and aspartate to plate- Dr L. Castera, Service d’Hepatologie, ˆ Hopital Beaujon, AP-HP, Clichy, let ratio index (APRI) the same day were studied. ´ Universite Denis Diderot Paris VII, France.