Vogt_Koyanagi_Harada综合征的临床表现及诊断_杨培增.pdf

·736 · 2002 12 38 12 　C in J Op t almol, December 2002, Vol 38, No.12 ·· Vogt-Koyanagi-Harada 杨培增　王红　周红颜　黄祥坤　钟华红　陈玲　钟晖　傅涛 　　【】　　Vogt-Koyanagi-Harada(VKH)、 。　1996 12000 12 157 VKH , 、、、(fundus fluorescein angiograp y, FFA)、 (indocyanine green angiograp y, ICGA)(HLA)。 　VKH (102 ,73.5%), 118 (80.8%); 、(100.0%); (128 , 98.4%)、(95.8%) Dalen-Fuc s (71.2%);、 、;(36.3%)(35.0%); FFA , ICGA 、;VKH HLA-DR4 HLA-DRw53 (54.9% 71.8%)(14.7% 38.2%)。 　VKH 、, 。 FFA、ICGA HLA VKH 。 【】　;　;　 Clinical manifestations and diagnosis of Vogt-Koyanagi-Harada syndrome 　YANGPeizeng, WANGHong, ZHOUHongyan, HUANG Xiangkun, ZHONG Huahong, CHEN Ling, ZHONG Hui, FU Tao.Zhongshan Ophthal ic Center, Sun Yat-sen University, Guangzhou510060, China Corresponding aut or:YANG Peizeng (Email:ypzn@gzsums.edu.cn) 【Abstract】　Objectiv e 　To investigate t e clinical features, causes of blindness and diagnosis of Vogt- Koyanagi-Harada (VKH)syndrome.Methods 　T e data of 157 patients wit VKH syndrome were reviewed and analyzed.Patients were carefully examined wit slit lamp, op t almoscope, t ree-mirror lens, fundus fluorescein angiograp y (FFA), indocyanine green angiograp y (ICGA)and HLA typing.Results 　Headac e was noted in 73.5%of t ese patients.Simultaneous involvement of bot eyes occurred in 80.8%of t ese patients.C roiditis, papilledema and edema of t e retina adjacent to t e optic nerve were noted in 100% of t ese patients in t e posterior uveitis stage, w ereas recurrent granulomatous anterior uveitis (98.4%), “sunset glow” fundus (95.8%)and Dalen-Fuc s nodules (71.2%)were t e common ocular findings in t e recurrent anterior uveitis stage.T e common causes of blindness were papillitis, exudative retinal detac ment and complicated cataract in t e posterior uveitis stage, anterior uveal involvement stage and its recurrent stage.Poliosis (36.3%)an