CLASS NO.1.ppt

* 无机化学 有机化学 金属有机 碳（氢)－金属键的形成和反应 A. Yamamoto: 有趣和有用 多样性与意外性 A. Yamamoto (1967): Ziegler-Natta catalyst: Transition metal complex + Main group metal compound [TiCl4 + AlEt3] in Ar Co(acac)3 + AlR3 + PPh3 CoH(N2)(PPh3)3 N2 MS of the gas from thermolysis: N2, H2, no O2. Excluded from the possibility of air leakage. Peal Harbor complex ! A. Yamamoto: Organotransition Metal Chemistry p. 140. The Nobel Prize in Chemistry 2001 for their work on chirally catalysed hydrogenation reactions William S. Knowles Ryoji Noyori St. Louis, MO, USA Nagoya University, Chikusa, Nagoya, Japan 1938 for his work on chirally catalysed oxidation reactions K. Barry Sharpless 1941 The Scripps Research Institute La Jolla, CA, USA 1917 - www.nobel.se 基于金属有机化学的化学工艺 (1) 钯催化的从乙烯出发合成乙醛(Wacker process) (2) Ziegler-Natta催化剂催化烯烃聚合; (3) Rh催化的烯烃氢化； (4) 美国孟山都公司Rh催化从MeOH和CO出发制备醋酸的工艺 (5) 联合碳化公司的Rh催化的氢甲酰化生产醛的工艺; (6) 孟山都公司从合成气出发合成乙二醇的生产流程； (7) DuPont公司的尼龙-66前体合成工艺； (8) BASF、Rohm Haas公司的丙烯酸酯生产工艺; (9) 日本高沙香料公司的薄荷醇的不对称合成 (10) 金属催化的不对称合成技术在药物合成工业的实际应用 W. Schlenk 2 Li + R2Hg 1951年发现二茂铁: 合成(P. L. Pauson, T. J. Kealy of Duquesene University) Nature 1951, 168, 1039. 1952: S. A. Miller et al. at British Oxygen Co. (already has this compound for three year) J. Chem. Soc. 1952, 632. 1952: R. B. Woodward, G. Wilkinson (Harvard Univ) E. O. Fischer (Univ. Munich) ferrocene structure based on physical measurement fell short of proof Shortly after: X-ray (Penn. State College and Oxford Univ.) C EN News 2001, Dec. 3, P. 37 烯烃－金属键理论 Dewar (1951)：Bull. Soc. Chim. France Chatt, Duncanson (1953): J. Chem. Soc. 用于说明Zeise’s salt 的结构 影响Hoechst-Wacker process