基于细胞水平药物筛选的微流控芯片系统研究进展 - 中国现代应用药学.PDFVIP

·综 述 · 基于细胞水平药物筛选的微流控芯片系统研究进展  庞磊，马立东，孟宪生* ，包永睿，王帅(辽宁中医药大学药学院，辽宁 大连 116600) 摘要：进入 21 世纪以来，药物筛选技术正朝着快速、高效的细胞水平筛选方面发展，微流控芯片技术作为现代生命科学 领域的重要研究工具，以其分析微型化、高通量化、可集成化和良好的生物相容性等特点，在细胞水平药物筛选方面引 起了广泛关注，并取得了一系列成果。国家“十二五”规划中启动科技重大专项“基于微流控芯片的新药研究开发关键 技术”，使得微流控芯片在药物筛选领域的研究达到了一个新的高度。本文主要综述了近年来基于细胞水平药物筛选的微 流控芯片系统的研究进展，并对其应用前景进行了展望。 关键词：微流控芯片；细胞培养；药物筛选；研究进展 中图分类号：R965.1 文献标志码：A 文章编号：1007-7693(2015)12-1518-08 DOI: 10.13748/ki.issn1007-7693.2015.12.027 Advances of Microfluidic Chip System in Cell-based Drug Screening Research * PANG Lei, MA Lidong, MENG Xiansheng , BAO Yongrui, WANG Shuai(College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian 116600, China) ABSTRACT: Since entering the 21st century, drug screening technology is developing fast and efficiently towards to the cellular level screening. As a promising platform for the exploration of modern life science, microfluidic chip technology, with its analysis of miniaturization, qualcomm quantitative, can be integrated and good biocompatibility, etc, has attracted increasing attention on cell-based drug screening, and adopted a series of achievements. In the 12th five-year plan, our country started the science and technology major projects, making microfluidic chip reached a new height in the field of drug screening. In this paper, the microfluidic chip system based on a cellular level of drug screening in recent years are reviewed. In addition, the further applications of microfluidic chip are prospected based on the current development. KEY WORDS: microfluidic chip; cell culture; drug screening; research progress 20 世纪 90 年代，为了适应对生物样品进行更 药物筛选是从天然或合成的化合物中筛选出 灵敏、更高效、快速分离分析的需要，瑞士的 Manz 高效的新药或先导化合物，对其进行生物活性和 和 Widmer