Drug Metabolism 药物代谢.pptxVIP

Chapter 2 Drug Metabolism;Drug metabolism;Definition of Metabolism;Pathways of Metabolism;Oral bioavailability;Clinical Significance;Contents;Metabolism Pre-exercise;Review Organic chemistryFunctional groups;Pathways of Metabolism;Phase I Reactions;Phase I Reactions;1, Oxidation and  Hydroxylation;CYP3A4;Aliphatic hydroxylationalkyl;Aliphatic hydroxylation alkyl;alkyl;Benzylic hydroxylation;Benzylic hydroxylation; Allylic hydroxylation;Machanism of action;Heteroatom, N ;N-Dealkylation;?-hydrogen oxidation ;N-Dealkylation;O- and S-Dealkylation;O- and S-Dealkylation;Conclusion;Alkene Epoxidation;Alkene;Aromatic hydroxylation;Aromatic hydroxylation;Aromatic hydroxylation;epoxidation;epoxidation;other oxidation ;2), Ruduction;2， Ruduction;Ruduction, Prontosil;3，Hydrolysis;Esters;Esters; amides; Phase I reactions ;Phase I reactions;Phase II Reactions;Phase II Reactions;1, glucuronic acid conjugation;Glucuronic acid conjugation;1, glucuronic acid conjugation;glucuronic acid conjugation;O---Glucuronides;N, S---Glucuronides;2, sulfate conjugation;sulfate conjugation;3, conjugation with amino acid;conjugation with amino acid;Phase II Reactions;Metabolism;Objects;