体外条件对不同类型灯盏花素缓控释制剂释放行为影响.pdf

164 药学学报ActaPharmaeeutieaSiniea 161—1 2008，43(11)：1 ·研究简报· 体外条件对不同类型灯盏花素缓控释制剂释放行为的影响 何 燕1…，曾祥腾2，潘卫三h (1．沈阳药科大学药学院，辽宁沈阳110016；2．广州市医药工业研究所缓控释制剂中心，广东广州510240) 关键词：凝胶骨架技术；渗透泵技术；灯盏花素；释放行为 中图分类号：R943 文献标识码：A 文章编号：0513—4870(2008)11—1161—04 Effectsof／nvitroconditionson behaviorofdifferentof release types and sustainedcontrolledreleaseformulationsof breviscapin HE Wei．san‘‘ Yanl”，ZENG Xiang—ten92，PAN (』．School Pharmaceutical ofPharmacy，ShenyangUniversity，Shenyang110016。China；2．Sustained—and Center PharmaceuticalResearch PreparationofGuangzhou Industry Institute，Guangzhou510240，China) Wag as and chosenthemodel osmotic Abstract：Insolublebreviscapin technology drug．Bi·layerpump matrix wereusedto the sustainedandcontrolledrelease gel technology prepare preparations． breviscapin indexto the Dissimilarityfactors∽)andsimilarityfactors∽)wereapplied鹪similarjudgmentcompare effectsof讥vitroconditionsonthereleasebehaviorofdifferentof sustainedand typesbreviscapin controlledrelease toleranceofinvitroreleaseconditionsof osmotic preparations．The bi—layer pump andmatrix were