健康青年人血管内皮功能及动脉弹性的MRI测量研究 贾 颖，陈金华，李 .DOC

健康青年人血管内皮功能及动脉弹性的MRI测量研究 贾 颖，陈金华，李 雪，张玉龙，向建波，方靖琴，王舒楠，张伟国（400042 重庆，第三军医大学大坪医院野战外科研究所放射科） [摘要]目的 评价MRI在测定血管内皮功能及动脉弹性中的作用，探讨各指标正常值参考范围。方法 选取年龄范围为（20～2226例完全健康的男性青年志愿者，利用3.0T MRI的稳态自由进动快速成像(Fast imaging with steady state free precession，TureFISP）(Flow-mediated dilation, FMD)及主动脉可扩张性(Aortic distensibility , AD)。 结果 股动脉FMD值为（11.26+2.67）%；升主动脉（Ascending aorta，AA（600.9+115.7）mm2（449.2+92.3）mm2，AD10.04+3.29）×10-3/mmHgproximal descending aorta，PDA369.6+59.8）mm2，心脏舒张末期的最小面积为（287.4+59.7）mm28.54+4.78）×10-3 /mmHgdistal descending aorta，DDA310.7+58.1）mm2，221.9+41.2）mm211.80+4.56）×10-3 /mmHg0.01），升主动脉、近段降主动脉、远段降主动脉三组收缩末期的最大面积及舒张末期的最小面积值比较均有显著差异（P0.01）。结论 利用MRI测量血管内皮功能及动脉弹性的各项指标，安全、无创、组织分辨力高、重复性好，有利于血管疾病的早期检出，可为临床早期干预治疗提供依据。 [关键词] 核磁共振成像；内皮功能；动脉弹性 [中图法分类号] R445.2；R816.2 Assess the vascular endothelium function and flexibility by MRI: a fundamental study Jia Ying, Chen Jinhua, Li Xue, Zhang Yulong, Xiang Jianbo, Fang Jingqin, Wang Shunan, Zhang Weiguo（Department of Radiology, Third Affiliated Hospital and Research Institute of Surgery, Third Military Medical University, Chongqing 400042, China） [Abstract] Objective To evaluate the role of MR in determining vascular endothelium function and artery flexibility and obtain normal reference ranges of each index. Methods Selected 26 healthy male young volunteers aged from 20 to 22 years, measured flow-mediated dilation (FMD) and aortic distensibility (AD) by 3.0T MRI through using fast imaging with steady state free precession（TureFISP）sequence. Results FMD value of femoral artery was（11.26+2.67）%；the largest area of ascending aorta（AA）proximal descending aorta(PDA) and distal descending aorta(DDA) in end-systole was (600.9+115.7)mm2, (369.6+59.8)mm2, (310.7+58.1)mm2, respectively, and the minimum area in end-diastole was(449.2+92.3)mm2, (287.4+59.7)mm2, (221.9+41.2)mm2, respectively. The AD value of AA, PDA and DDA was (10.04+3.29)×10-3/mmHg, (8.54+4.78)×10-3/mmHg, (11.80+4.56)×10-3/mmHg, respectively. The femoral artery diamete