肿瘤特异性生长因子与子宫内膜癌血管生成及转移的关系.pdfVIP

852 Clinica1 Medical Journal of China，2O()7．Vo1．14，No．6 中国ff缶床医学 2007年 12月 第14卷 第6期 论著 肿瘤特异性生长因子与子宫内膜癌 血管生成及转移的关系 虞 斌 许培箴 张 蓉 王秋伟 周 红 摘要 目的：探讨血清肿瘤特异性生长因子(TSGF)检测与子宫内膜癌血管生成、浸润转移的关系。方法：采集33例子宫内 膜癌患者静脉血，采用化学比色法、El ISA检测血清TSGF、血管内皮生长因子(VEGF)、基质金属蛋白酶2(MMP一2)及基质 金属蛋白酶9(MMP一9)的含量，并与子宫肌瘤患者及正常妇女比较。结果：子宫内膜癌患者血清TSGF、MMP一2及MMP一9含 量均明显高于子宫肌瘤患者，差异有统计学意义(P()．05)，VEGF略有升高，但无显著差异(PO．05)；与正常妇女相比，水 平均明显升高(PO．05)。子宫肌瘤患者血清TSGF、VEGF、MMP 2及MMP 9与正常妇女相比无显著差异(P0．05)。结 论：与VEGF相比，TSGF可特异性地刺激恶性肿瘤的血管生成，TSGF、MMP 2及MMP一9在肿瘤的浸润转移中发挥重要作 用。 关键词 子宫内膜癌； 肿瘤特异性生长因子； 血管内皮生长因子； 基质金属蛋白酶2； 基质金属蛋白酶9 中图分类号 R737．33 文献标识码 A Relationship between Serum TSGF and Tumor Angiogensis，Invasion，Metastasis in Endometrium Carcinoma yU Bin XU Peizhen ZH|ANG Rong WA G Qiuwei ZH0 Hong The Maternity and Infant Health Hospital of Changzhou City in Jiang’SH Province。ChangzhOH 21 3()03 Abstract Objective： Fo study the relationship between serum tumor specific growth factor(TSGF)level and tumor angiogen— sis，invasion，metastasis in endomet rium carcinoma．Methods：We collected the blood of the patients with carcinoma of endome— trium．and examined the level of TSGF．vascular endothelial growth factor(VEGF)，matrix meta110proteinase一2(MMP一2)and matrix meta11oproteinase一9(MMP一9)．then compared with hysteromyoma patients and heahhy controls．Results：Statistical sig nificance of the levels of TSGF VEGF，MMP一2 and MMP一9 were found when endometrium cancer group was compared with control group(P()．05)．Compared with the patients of hysteromyoma，the levels of TSGF，MMP一2 and MMP一9 were great— ly higher(P0．05)，but there was no significant difference in the level of VEGF(P0．05)．The levels of TSGF，MMP～2 and MMP一9 were similar between the hysteromyoma and normal group(P 0．05)．Conclusion：Serum TSGF associated with MMP一2 and MMP一9 may work on minor invasion and met