抑郁症的静息态脑功能磁共振研究.PDFVIP

27 1 Vol.27 No. 1 2010 2 Journal of Biomedical Engineering February 2010 * 1 1 1$ 2 2 1 李东明 黄晓琦 吴杞柱 邹 可 孙学礼 龚启勇 1( 四川大学 华西医院放射科磁共振中心( HM RRC), 成都610041) 2 ( 四川大学 华西医院 心理卫生中心,成都610041) :DSM-IV 53 38 , ( regional ho ogeneity, ReHo) ,, , (anterior cingulate cortex, ACC) ReHo ACC ReHo :; ;; R7491 4; R445. 2 A 1001-5515(2010) 01-0016-04 Brain Functions in Major De ressive Disorder: A Resting-state Functional Magnetic Resonance Imaging Study 1 1 1 2 Li Dongming Huang Xiaoqi Wu Qizhu Zou Ke 2 1 Sun Xueli Gong Qiyong 1(H uaxi MR Research Center (H MRRC) , West China H osp ital, Sichuan University , Chengdu 610041, China) 2 (Department of sy chology , West China H osp ital, Sichuan University , Chengdu 610041, China) Abstract: This study sought to reveal the difference in resting-statebrain functions between subjects with ajor de- pressive disorder and nor al controls. Fifty-three depressed patients diagnosed with DSM-IV and 38 nor al controls underwent resting-state functional agnetic resonance i aging ( fMRI), and the data were analyzed using a new ethod called Regional Ho ogeneity (ReHo). T hen voxel wised co parison was ade to derive the resting-state brain function differences between groups. Co pared with nor al controls, depressed subjects showed decreased Re- Ho in bilateral anterior cingulate cortex ( ACC) , left edial f