EPO在分化型甲状腺癌中的表达及意义.pdfVIP

目 录 中文摘要·············································································1 英文摘要·············································································3 英文缩写·············································································5 研究论文 EPO 在分化型甲状腺癌中的表达及意义 前言·············································································6 材料与方法····································································8 结果·············································································11 附图·············································································13 附表·············································································15 讨论·············································································17 结论·············································································21 参考文献 ·······································································22 综述 EPO 与甲状腺癌的研究进展 ·············································26 致谢···················································································35 个人简历·············································································37 万方数据 中 文 摘 要 EPO 在分化型甲状腺癌中的表达及意义 摘 要 目的：近年来，甲状腺癌的发病率在世界范围内呈上升趋势，尽管大 多数甲状腺癌通过手术和药物治疗效果良好，但仍有 10%-20% 的病人死 于肿瘤的低分化和进展。甲状腺癌根据组织学可以分为分化型和未分化 型。分化型甲状腺癌又可分为甲状腺乳头状癌（Papillary thyroid carcinoma，PTC ）和甲状腺滤泡癌（Follictalar thyroid carcinoma，FTC ）， 前者占全部甲状腺癌的 75%，后者占 16%。目前尚缺乏可有效鉴别甲状 腺结节良恶性及预测预后的肿瘤标记物。目前，促红细胞生成素 （Erythropoietin ，EPO ）在肿瘤发生、发展中的作用正成为研究的热点。 EPO 在甲状腺癌中的表达及它和甲状腺癌生物特征的关系还没有明确的 定论。本研究旨在探讨EPO 在分化型甲状腺癌中的表达及意义，帮助寻 找一种特异性、敏感性较高的甲状腺癌肿瘤标记物，用于早期诊断，提出 合理治疗方案