李德发20151024 Advanced Research in Swine Nutri,农科院,北京.pptVIP

Dietary fiber Gut microbiota composition Fermentation capability GPR43 SCFA Lymph duct/Portal vein Subcutaneous fat Back fat Intramuscular fat Visceral fat Signaling and regulatory factors Structure Activity Biological function Transporters Permeability Obesity Pork quality Adipose tissue Lipogenesis Lipolysis Leptin or liponectin secretion Host energy homeostasis PYY Secretion GLP1 Secretion Intestine mortility Intestine Bifidobacterium Acetate FA Bacteriodetes Propionate Glu Faecalibacterium Butyrate Energy （Breeds） Metatranscriptomics Proteomics Mechanisms of gut micobiota metabolism in human and pigs SLC5A8 transport Butyrate Inhibitor of HDACs HDACs inhibitor = anticancer agents （Processing Technology） HDP expression Neutrophil Killing pathogens in gut （Type） TGR5 Cholesterol 7 a-hydroxylase (HSDHs) DCA Streptococcus Clostridium Bacteriodetes Secondary bile acid DNA Damage Liver Cancer Pancreatic/Liver function Insulin sensitivity Decrease obesity + Firmicutes - Primary bile acids (conjugated) Primary bile acids (unconjugated) Bile?salt hydrolases (BSHs) Obesity Bacteroidetes↓ Type 2 Diabetes Clostridium↓ Produce Dietary source of bacteria or nutrients Gut stem cells related with nutition +4 stem cell Bmi1 Defenders Lysozyme Barrier function Damage repair Absorptive enterocytes Transporters SGLT1, PepT1 Transit amplifying cells Progenitor cells Snai1 Regulatory effect Microbiota 生物胺 Bile Salts Nutritions ? Stem cells in small intestine mucin GLP-1 HDP、IgA Secretory enterocytes CBC Lgr5 stem cell Enterocyte Goblet cell Paneth cell Entero- endocrine cell Microbiota affects host metabolism in gut and liver Microbial DNA and LPS in blood NLRP 3/6 Effector protein ( IL18 ) Adipose inflammation TLR4 LPS + Peptidoglycan NOD1 Insulin resistance CCL5 Permiability * Type-2 Diabetes * Visceral adiposity Hepatic steatosis NAFLD/NASH TNFαsecretion TLR 4/9 activation + Altere