Insulin-like growth factor 1 can promote the,IGF-1R 南京医科大学(英文版).pdfVIP

Stem Cell Research (2012) 8, 346–356 A v a i l a b l e o n l i n e a t w w w . s c i e n c e d i r e c t . c o m w w w . e l s e v i e r . c o m / l o c a t e / s c r Insulin-like growth factor 1 can promote the osteogenic differentiation and osteogenesis of stem cells from apical papilla Sainan Wang a , b, 1, Jinquan Mu c , 1, Zhipeng Fan d , Yan Yu a , Ming Yan a , Gang Lei a , Chunbo Tang a , e , Zilu Wang a , Yangyu Zheng a , Jinhua Yu a , f ,⁎, Guangdong Zhang a , f ,⁎⁎ a Institute of Stomatology, Nanjing Medical University, 140 Hanzhong Road, Nanjing, Jiangsu 210029, China b Department of Endodontics, Peking University School and Hospital of Stomatology, 22 Zhongguancun Nandajie, Haidian District, Beijing 100081, China c Nanjing Maternal and Child Health Care Hospital, 123 Tianfei Street Mochou Road, Nanjing, Jiangsu 210004, China d Molecular Laboratory for Gene Therapy Tooth Regeneration, School of Stomatology, Capital Medical University, 4 Tian Tan Xi Li, Beijing 100050, China e Prosthetic Department, School of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, Jiangsu 210029, China f Endodontic Department, School of Stomatology, Nanjing Medical University, 136 Hanzhong Road, Nanjing, Jiangsu 210029, China Received 25 July 2011; received in revised form 7 December 2011; accepted 12 December 2011 Abstract Insulin-like growth factor 1 (IGF-1) plays an important role in the regulation of tooth root development, and stem cells from apical papilla (SCAPs) are responsible for the formation of root pulp and dentin. To date, it remains unclear whether IGF-1 can regulate the function of SCAPs. In this study, SCAPs were isolated and purified from human immature root apex, and stimulated by 100 ng/mL exogenous IGF-1. The e