一氧化氮在心肌缺血再灌注损伤中的调节作用及相关治疗 - 药学进展.pdf

PROGRESS IN PHARMACEUTICAL SCIENCES 2016,40 2 :96-103 96 ( ) 一氧化氮在心肌缺血再灌注损伤中的调节作用 及相关治疗药物研究进展 马雯奂，韩丹，方伟蓉，李运曼* ( 中国药科大学生理教研室，江苏 南京 210009) [ 摘要 ] 一氧化氮 ( NO ) 是体内调节心血管系统功能的重要信号分子，在血管收舒、血小板活性调节、细胞增殖凋亡、氧化应激及炎症反 应等过程中发挥了不可或缺的作用。在心肌缺血再灌注过程中，随着一氧化氮合成酶表达和 NO 底物水平的动态变化，NO 生成的时间和 产量均会发生变化，导致其作用具有两面性。综述 NO 的产生与作用、在心肌缺血再灌注损伤中的作用和影响因素以及相关治疗药物及作 用机制的研究进展，为心肌缺血再灌注损伤的有效治疗和进一步研究提供参考。 [ 关键词 ] 一氧化氮；一氧化氮合成酶；心肌缺血再灌注损伤；作用机制；一氧化氮相关药物 [ 中图分类号 ] R542.2 [ 文献标志码 ] A [ 文章编号 ] 1001-5094（2016）02-0096-08 Nitric Oxide in Myocardial Ischemia-Reperfusion Injury: Regulating Role and Related Drugs MA Wenhuan, HAN Dan, FANG Weirong, LI Yunman (Department of Physiology, China Pharmaceutical University, Nanjing 210009, China) [Abstract] Nitric oxide ( NO ), as a signaling molecule, plays important roles in regulating cardiovascular system, including vasoconstriction/ vasodilation, platelet activation, cell proliferation/apoptosis, oxidative stress, inflammation, etc. During myocardial ischemia-reperfusion, both the generation time and the level of NO change along with the transformation in nitric oxide synthase expression and NO substrate level, resulting in its contrary effects. The generation and function of NO, its roles in myocardial ischemia- reperfusion injury and influencing factors, as well as related drugs and their mechanisms of action were reviewed so as to provide references for the effective treatment and further research of myocardial ischemia- reperfusion injury. [Key words] nitric oxide; nitric oxide synthase; myocardial ischemia-reperfusion injury; mechanism of action; nitric oxide related drug 长期以来，心肌缺血 ( myocardial ischemia ) 一直是威 其突出的生物学意义被 Science 杂志评为 “