不同操作方法对多西他赛药物残留量的影响 - 中国药房.pdf

不同操作方法对多西他赛药物残留量的影响 ＊ # 张惠霞 ，周 珺，李茂星 ，贾正平（兰州军区兰州总医院药剂科，兰州 730050） 中图分类号 R979.1 文献标志码 A 文章编号 1001-0408（2016）01-0142-03 DOI 10.6039/j.issn. 1001-0408.2016.01.47 摘 要 目的：探讨不同操作方法对多西他赛药物残留量的影响。方法：选取多西他赛注射液60支，A 组（30支）采用按说明书要 求的标准操作方法，B 组（30支）采用临床通用的常用操作方法，分别放置5、10、15min 抽取药液后收集残留液，计算药物残留量， 比较因操作配制方法、放置时间不同所产生的残留量差别。结果：在放置5、10、15min 时，B 组的平均残留液体积及药物残留量 均高于A 组（P ＜0.05）。同组内比较，放置10、15min 时平均残留液体积及药物残留量均低于放置5min 者（P ＜0.05或P ＜0.01）， 且放置15min 时平均残留液体积及药物残留量也均低于放置10min 者（P ＜0.05）。结论：调配人员的规范操作对减少多西他赛残 留量，保证患者安全、有效、足量的用药至关重要。建议临床工作者按标准操作规程操作。 关键词 多西他赛注射液；残留量；操作方法 Effects of Different Operation Methods on the Residual Amount of Docetaxel ZHANG Huixia ，ZHOU Jun ，LI Maoxing ，JIA Zhengping （Dept. of Pharmacy ，Lanzhou General Hospital of Lan- zhou Military Command ，Lanzhou 730050，China ） ABSTRACT OBJECTIVE ：To investigate the effects of different operation methods on the residual amount of docetaxel. METH- ODS ：60 Docetaxel injections were selected and divided into two groups ，i.e. standard operation method was adopted in group A （30 injections ），and clinical common operation method was used in group B （30 injections ）. Docetaxel injections were placed for 5，10or 15minutes respectively ，and drained. Residual liquid was collected to calculate residual amount. The difference of residual amount ，due to preparation method and standing time ，were compared between two groups. RESULTS ：After placing for 5，10or 15min ，the volume and amount of residual liquid in group B were significantly higher than in group A （P ＜0.05）. In same group ， the volume and amount of residual liquid after placing for 10and 15min were all lower than that after placing for 5min （P ＜0.05 or P ＜0.01）；the volume and amount of residual liquid after placing for 15min were lower than that after placing for 10min （P ＜ 0.05）. CONCLUSIONS ：The standard operation of pharmacy