长期口服小剂量伐地那非治疗按需服药无效ED的疗效观察.pdfVIP

·412 · Journal of Clinical Urology ，Jun 2008，Vol 23，No 6 长期口服小剂量伐地那非治疗按需服药 无效ED的疗效观察 武志刚 翁志梁 蔡健 李湘斌 李澄棣 [摘要] 目的：评估持续口~ll／d,剂量伐地那非治疗按需服药无效的勃起功能障碍(ED)患者的疗效及停药后 效果维持状况。方法：将按需服药无效的39例ED患者改用长期口服小剂量伐地那非治疗3个月，在治疗前后 及停药后3个月分别记录患者国际勃起功能指数一5(International index of erectile function-5，IIEF-5)评分及患者 性生活日记中插入和保持勃起的成功率，并且记录治疗前后夫妻性满意度。结果：本组患者治疗后主要疗效指标 均高于治疗前，且治疗前后指标差异有统计学意义(PO．O1)；停药后3个月，主要指标仍高于基线水平，且差异 有统计学意义(PO．05)。结论：每天口服小剂量伐地那非对约半数(48．6 )按需服药无效的ED患者，可改善 勃起功能，且安全、有效。 [关键词] 勃起功能障碍；药物治疗；伐地那非 [中图分类号] R698 [文献标识码] A [文章编号] 1001—1420(2008)06—0412-03 Chronic low dose vardenafil in men with erectile dysfunction previously unresponsive to on-demand treatment WU Zhigang WENG Zhiliang CAI Jian L Xiangbin L Chengdi ( Depatment of Urology，the First Affiliated Hospital of Wenzhou Medical College，Wenzhou， 325000，China) Abstract Objective：Evaluate the efficacy of chronic oral low dose vardenafil in men with erectile dysfunction (ED)previously unresponsive tO on-demand treatment and discontinuing the drug whether ED will reappear．Meth- ods：39 ED patients of previously unresponsive tO on-demand treatment received 3-month therapy of chronic low dose vardenafil，IIEF-5 and diary recorded success rate for penetration and maintenance of erection during the in- tercourse were recorded and compared pre-treatment and duration of therapy and after treatment and after discon— tinuing the drug 3-month respectively．Coitus satisfaction degree of patients with ED and partners were recorded before and after treatment．Results：The primary study endpoints of the group were superior to pre-treatment ago， and significant difference could