1 系统性红斑狼疮早发冠心病患者传统危险因素及冠状动脉病变分析 .doc

系统性红斑狼疮早发冠心病患者传统危险因素及冠状动脉病变分析 刘丽，张抒扬，张婷婷 【摘要】 目的 研究女性系统性红斑狼疮（SLE）（CAD）危险数目及冠脉病变严重程度。结果 传统危险因素及传统危险因素数目1.6±0.8）（1.8±1.0）无明显差异（P0.05）。两组冠脉狭窄支数无明显差异（P0.05）SLE组冠脉三支病变的比例明显高于P0.05]。结论 SLE早发CAD患者ystemic lupus erythematosus patients with premature coronary atherosclerotic heart disease LIU Li, ZHANG Tingting, ZHANG Shuyang. Department of Cardiology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China Corresponding author:ZHANG Shuyang, Email: shuyangzhang103@163.com 【Abstract】 Objectives . Methods Comparison of traditional risk factors (hypertension, diabetes, high cholesterol, family history of premature coronary artery disease, early menopause, and smoking), the number of traditional risk factors and the severity of coronary artery disease between 11 female premature CAD patients with SLE and 63 female premature CAD patients without SLE (age≦60 years) diagnosed by coronary angiography. Results No significant difference between two groups in all traditional risk factors, the number of traditional risk factor [(1.6±0.8) vs (1.8±1.0)]and the number of coronary stenosis (P0.05) , but the proportion of three coronary artery lesion was more higher in SLE group than that of non SLE group [(7/11) vs (17/64), P0.05]. Conclusions The traditional risk factors of female SLE patients with premature CAD did not significantly reduce, but their coronary artery lesion are more extension. 【Key words】 Lupus erythematosus, systemic; Risk factors; Coronary artery disease Coronary angiography 冠状动脉粥样硬化性心脏病（CAD）对SLE患者尤其是年轻女性SLE患者的危害已逐渐为人们所认识 [1-2]。但多数关于SLE并发CAD的研究[2-4]未能应用冠状动脉造影（CAG）这一金标准来明确CAD的诊断，未除外冠状动脉炎、动脉血栓及心肌病变患者。本研究回顾性分析了经CAG确诊的女性SLE早发CAD患者的传统危险因素患病情况及冠脉病变特点，来进一步明确传统危险因素在SLE并发CAD中的作用及SLE对于冠脉病变的影响。 对象与方法 1.研究对象：SLE组为11例1983年至2013年在北京协和医院诊断为SLE合并CAD的年龄≦60岁的女性患者。对照组为6例2011年至2013年我院诊断的年龄≦60岁的非SLE早发CAD女性患者。SLE的诊断符合美国风湿病学会1997年推荐的的SLE分类标准。CAD的诊断均通过证实。排除临床资料不完整第一次心脏事件发生在确诊SLE之前的病例。 2.研究方法：采用SPSS19.0软件包进行统计学处理，计