湿阻中焦证病机的实验分析—平胃散及其化裁对大鼠湿阻中焦证醛固酮、心钠素、神经降压素的变化影响.pdfVIP

中文摘要 目的：以现代医学微观的思维方式。探究宏观的湿阻【}]搏证的病机及平 冒散、拆方和加味方对湿阻中焦证的作用机理。方法：选用大鼠湿阻中焦证 动物模型，并用平胃散全方、拆方和加味方予以治疗，观察各组大鼠血浆醛 焦证ALD降低，ANP增加，NT增加。经平胃散全方、拆方和加味方治疗后， ALD、ANP有逐渐恢复正常的趋势：NT基本恢复正常。结论：1．大鼠湿阻中焦 证体重、体温、进食量、饮水量皆下降，经平胃散全方、拆方和加味方治疗 后，体重、进食量、饮水量皆增加，体温恢复正常。2．大鼠湿阻中焦证表现为 水电解质代谢和肠道运动紊乱，从而导致血浆ALD、ANP、NT变化。3．平胃散 能调节ALD、ANP、NT等因素的紊乱，直接改变湿阻中焦证，使之逐步康复。 关键词：湿阻中焦证 平胃散 醛固酮 心钠素 神经降压素 ABSTRACT OBJECTIVE：Tointothe essenceof probe generallypathological ofaccumulationin andthe syndrome Middle--Jiaomechanismofthe ofdampness andmodificationsof totreat whichused the whole，parts Pingweisan syndrome ofaccumulationof inMiddleJiaodirect ofmodem dampness by thoughtway medicine．METHOD：Theof of accumulation inMiddle— syndrome dampness inrats and Jiao weremodeledtreatedthe andmodificationsof by whole，parts ofALD、ANpandNTof were Pingweisan．Meanwhile．thedensity every group measured．RESULTS：Intheratsof ofaccumulationof in syndrome dampness ofALDwas of MiddDJiao,the the ANPandNT density lower,whiledensity thecureof the andmodificationsof higher．After