细胞自噬和人类疱疹病毒相互作用的研究进展黄媛.pdfVIP

Chinese Journal of Cell Biology 2014, 36(8): 1207–1212 DOI: 10.11844/cjcb.2014.08.0057 (, 430030) , , , , , , , ; ; ; ; Advances in Interaction between Autophagy and Human Herpes Virus Huang Yuan, Liu Xinglou, Fang Feng* (Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China) Abstract Autophagy is one of self-protection mechanisms that ubiquitously exists in eukaryotes. With the participation of autophagy-related proteins, autophagy forms complete and complex phagocytosis mechanism as well as self-regulation mechanism. Except for its function in maintaining homeostasis, autophagy can also recog- nize invaders such as human herpes virus, and then remove them away. Human herpes virus is worldwide pathogen that causes universal infection. During long-term mutual adaptation with host, human herpes virus has evolved ex- tremely robust strategies to destroy and block the clearance function of autophagy. Key words autophagy; autophagy-related proteins; human herpes virus; immune elimination; immune evasion , ( )[3], , , – , , , , [4] , ()[5], , (xenophagy), [1-2], (autophagy-related proteins, Atg) : 2014-02-26 : 2014-04-25 : (1)Atg7 (: 8130142581271807) *Tel: 027 E-mail: ffang@ Atg10, Atg5Atg12, Atg5-Atg12 Received: February 26, 2014 Accepted: April 25, 2014 Atg16; (2)Atg4LC3( This work was supported by the National Natural