磁小体研究进展 - 中国农学通报.pdf

中国农学通报 2011,27(24):8-12 Chinese Agricultural Science Bulletin 磁小体研究进展 高宗良，谷元兴，赵 峰，刘永生 （中国农业科学院兰州兽医研究所/家畜疫病病原生物学国家重点实验室 农业部畜禽病毒学重点开放实验室/农业部兽医公共卫生重点开放实验室，兰州730046） 摘 要：趋磁细菌（magnetotactic bacteria, MTB ）能够在细胞内合成由生物膜包裹的纳米级磁铁矿粒子 ——磁小体（magetosome ）。磁小体的合成过程，尤其是铁离子的反应途径及吸收转运受到严格的生物 调控。磁小体完美的晶体结构使其在医学成像、磁介导热疗、药物输送等众多领域都有良好的应用价 值。主要综述了磁小体矿化过程中铁的反应途径和吸收转运系统，以及磁小体在各方面的应用，并对未 来的研究方向做了展望。 关键词：磁小体；铁反应途径；吸收转运；应用 中图分类号：Q939.9 文献标志码：A 论文编号：2011-1460 ProgressintheStudyofMagnetosome GaoZongliang,GuYuanxing,ZhaoFeng,LiuYongsheng (Key Laboratory of Veterinary Public Health of the Ministry of Agriculture/Key Laboratory of Animal Virology of the Ministry of Agriculture/State Key Laboratory of Veterinary Etiological Biology/ Lanzhou Veterinary Research Institute Chinese Academy of Agricultural Sciences,Lanzhou730046) Abstract: Magnetotacticbacteria(MTB)arecapableofformingnano-magnetiteparticlesenvelopedbya biologicalmembrance in vivo,whicharecalledmagnetosome.Thebiosynthesisofmagnetosomeespecially mechanismsofironuptakeandtransportprocesswithverystrictcontrols.Thecrystallographicperfectionof magnotosome has attracted interest in its use as magnetic nanoparticles in medical imaging, magnetic-mediated hyperthermia, drug delivery and other fields. This paper reviews the magnetosome biomineralizationmainlyonthepathwayofironreactionandironuptaketransportsystem,describesthe magnetosomeintheapplicationoftheaboveandputforwardthefuturedirections. Keywords：magnetosome;ironreactionpathway;ironuptakeandtransport;applications 0 引言 含有对磁场具有敏感性的磁小体，它起了导向作用，同