丹龙醒脑片对血瘀证家兔血液流变性和球结膜微循环的影响.pdf

2006年 1月第 13卷第 1期 中国中医药信息杂志 ·37· 丹龙醒脑片对血瘀证家兔血液流变性和 球结膜微循环的影响 周小青,刘旺华,李 花,邓常青,刘建新 (湖南中医学院中医诊断研究所,湖南 长沙 410007) 摘要：目的 研究丹龙醒脑片(DLXNP)对血瘀证家兔血液流变性和球结膜微循环的影响,以探讨其活血化瘀功 效。方法 从耳缘静脉注射高分子右旋糖酐(dextran500)复制血瘀证家兔模型,观察其血液流变性和球结膜微循环 改变以及丹龙醒脑片对该模型的影响。结果 造模后,模型组全血粘度、全血还原粘度显著升高,血沉(ESR)明显加 快,血沉方程 K 值(ESRK)升高,红细胞聚集指数及红细胞变形指数升高,球结膜微循环形态积分和总积分明显增高 (P 0.01～0.05)。与模型组相比,丹龙醒脑片各组全血粘度、血沉方程 K 值、红细胞聚集指数、红细胞变形指数 显著降低,球结膜微循环形态积分和总积分亦有显著降低(P 0.01～0.05)。结论 丹龙醒脑片能改善高分子右旋 糖酐所致血瘀证家兔模型血液流变性,改善微循环障碍。这可能是其活血化瘀作用的机制之一。 关键词：丹龙醒脑片；血瘀证；高分子右旋糖酐；血液流变学；球结膜；微循环；兔 中图分类号：R285.5 文献标识码：A 文章编号：1005-5304(2006)01-0037-03 The Effects of DLXNP on Hemorrheology and Bulbar Conjunctiva Microcirculation of Blood Stagnant Syndrome in Rabbits Models ZHOU Xiao-qing, LIU Wang-hua, LI Hua, et al (Institute of Diagnosis of TCM, Hunan College of TCM, Changsha 410007, China) Abstract ：Objective To investigate the effects of DLXNP on hemorrheology and bulbar conjunctiva microcirculation (BCM) in rabbit and to explore its effects of activating the blood and eliminating the stagnant. Methods The blood stagnant syndrome model was reproduced by injecting dextran 500 into the marginal ear vein. The BCM and the hemorrheology properties were detected and compared. Results Compared with the normal group, the model groups indexes of whole blood relative and whole blood reducing viscosity improved (P 0.01 ～0.05), erythrocyte sedimentation rate (ESR) became quicker, erythrocyte sedimentation rate K (ESRK) increased, erythrocyte aggregation index and erythrocyte transmutation index increased, BCMs morphological mark and total mark increased (P 0.01). Compared with th