普利他膜衣锭300毫克prezista film coated tablets 300 mg.pdf

利300 Prezista Film Coated Tablets 300 mg 024764 PREZISTA™ (darunavir) 類不(HIV)PREZISTA™ (darunavir) darunavir ethanolate [(1S, 2R)-3-[[(4- aminophenyl)sulfonyl](2-methylpropyl)amino]-2-hydroxy-1-(phenylmethyl)propyl]- carbamic acid (3R, 3aS, 6aR)-hexahydrofuro[2, 3-b]furan-3-yl ester monoethanolate C H N O S • C H OH 量 593.73 27 37 3 7 2 5 Darunavir ethanolate Darunavir ethanolate20°C度0.15 mg/mL PREZISTA300MG TMC114 粒300mg darunavir darunavir ethanolate colloidal silicon dioxide crospovidone magnesium stearate and microcrystalline cellulose --OPADRY® Orange FDC Yellow No 6, polyethylene glycol 3350, polyvinyl alcohol-partially hydrolyzed, talctitanium dioxide PREZISTA量不darunavir MICROBIOLOGY [Mechanism of Action ] Darunavir HIV-1 HIV encoded Gag-Pol 裂 粒 [Antiviral Activity ] 臨離HIV-1 HIV-2T類 /darunavirHIVEC 1.2 ~ 8.5 nM (0.7 ~ 50 5.0 ng/mL) Darunavir HIV-1 M (A, B, C, D, E, F, G) O離EC50 0.1 ~ 4.3 nM darunavirEC50數5.4度Darunavir amprenavir, atazanavir, indinavir lopinavir, nelfinavir, ritonavir, saquinavirtipranavir, the N(t)RTIs abacavir, didanosine, emtricitabine, lamivudine, stavudine, tenofovir, zalcitabine, zidovudine, the NNRTIs delavirdine, efavirenz nevirapine enfuvirtide [Resistance ] darunavir/ritonavir療darunavir降HIV-1離 來 來HIVdarunavir darunavir降6~21 3 ~ 6 列 S37N/D, R41E/S/T, K55Q, K70E, A71T, T74S, V77II85V 9 HIV-1離darunavir 22L10F, V11I, I13V, I15V, G16E, L23I, V32I, L33F, S37N, M46I, I47V, I50V, F53L, L63P, A71V, G73S, L76V, V82I, I84V, T91A/SQ92R L10F, V32I, L33F, S37N, M46I, I47V, I50V, L63P, A71VI84V見 darunavir 8降darunavir 50~641 EC 125 nM ~3461 nM