LCK-HCK-FGR介导的负调控其酪氨酸磷酸化抑制的抗病毒天然免疫反应.pdfVIP

Article Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses Graphical Abstract Authors Shengduo Liu, Shasha Chen, Xinran Li, ..., Jian Zou, Xin-Hua Feng, Pinglong Xu Correspondence xupl@ In Brief Liu et al. report the Src family kinases (SFKs) Lck, Hck, and Fgr directly phosphorylate TBK1, a core player in antiviral immunity, to prevent its dimerization and activation, which dampens antiviral defenses in zebrafish and mice. SFKs are induced by antiviral immune signaling, thus constituting a negative feedback loop. Highlights d TBK1 is dynamically tyrosine-phosphorylated by Src kinases (SFKs) during viral infection d Antiviral responses induce expression of SFKs Lck/Hc