肾结石患者体内丛生蛋白和炎症指标表达水平的临床研究 - 中国临床医学.doc

肾结石患者体内丛生蛋白和炎症指标表达水平的临床研究 彭泳涵1△，刘敏1△，施晓磊1，陈锐1，李凌1，高小峰1,周铁1 第二军医大学附属长海医院泌尿外科，上海 200433） [摘要] 目的：研究肾结石患者体内丛生蛋白表达及炎症反应水平。方法：收集上海长海医院泌尿外科2015年7月~9月间住院肾结石成人患者及体检中心健康体检成人的临床资料及血尿标本，并分为结石组和对照组，采用酶联免疫吸附试验检测两组人群血液和尿液中丛生蛋白水平，以及血液中炎症反应指标并进行对比分析。结果：结石组纳入47例，中位年龄43.00（33.50-50）岁；对照组纳入56例，中位年龄38.50（32.50-53.00）岁，两组间年龄和性别差异无统计学意义（P0.05）。结石组血液丛生蛋白水平低于对照组 [156.85（151.51-195.09）ng/ml vs. 171.48（151.51-195.09）ng/ml，P0.01]，两组间尿液丛生蛋白水平差异无统计学意义 [52.76（42.66-57.37）ng/ml vs. 53.37（44.40-68.07）ng/ml，P0.05]。结石组血液白介素1β水平高于对照组 [17.92（16.26-19.18）ng/L vs. 13.55（12.06-17.76）ng/L，P0.01]，结石组血液白介素6水平高于对照组 [53.22（46.04-71.46）ng/L vs. 46.58（42.34-52.63）ng/L，P0.01]。结论：肾结石患者血液丛生蛋白水平降低，炎症反应水平升高。 [关键词] 肾结石；炎症反应；丛生蛋白；白介素 Clinical research on expression of clusterin and inflammation biomarkers in patients of nephrolithiasis PENG Yonghan1△, LIU Min1△, SHI Xiaolei1, CHEN Rui1, LI Ling1, ZHOU Tie1, GAO Xiaofeng1 1. Department of Urology，Changhai Hospital，Second Military Medical University，Shanghai 200433，China Abstract Objective：To investigate the level of clusterin and inflammation reaction in patients of nephrolithiasis. Methods：Clinical materials, blood and urine samples of inpatients with nephrolithiasis and healthy adults were collected from Jul to Sep 2015 in Shanghai Changhai Hospital, and ELISA tests were conducted to detect serum and urine clusterin level, as well as serum inflammation biomarkers, to make comparison between both groups. Results：47 cases with median age of 43.00(33.50-50)yrs and 56 cases with median age of 38.50(32.50-53.00)yrs were recruited in the stone and control group respectively, and there were no statistically significant differences between two groups in age and sex(P0.05). Serum clusterin level was lower in renal stone patients than the control group [156.85(151.51-195.09)ng/ml vs. 171.48(151.51-195.09)ng/ml, P0.01], while urine clusterin level had no statistical significance compared with the control group [52.76(42.66-57.37)ng/ml vs. 53.37(44.40-68.07)ng/ml, P0.05]. Ser