龙须藤提取物镇痛抗炎作用的研究.pdfVIP

摇 广东药学院学报 摇 Journal of Guangdong Pharmaceutical University摇 Dec.2012,28(6) 龙须藤提取物镇痛抗炎作用的研究 易荆丽,张嘉家,周毅生,王嵩,赵永恒 (广东药学院 中药学院,广东 广州510006) 摘要:目的研究龙须藤乙醇提取物的镇痛抗炎作用,筛选出龙须藤镇痛抗炎作用的有效部位。 方法 采 用热板法和冰乙酸扭体法观察镇痛作用,采用二甲苯致小鼠耳郭肿胀法观察抗炎作用。 结果 龙须藤醇 提物具有较好的镇痛抗炎作用;龙须藤醇提物的乙酸乙酯萃取物和正丁醇萃取物具有显著的镇痛作用 并能较好抑制炎症的组织液渗出。 结论 龙须藤醇提物的乙酸乙酯部位和正丁醇部位可能是龙须藤镇 痛抗炎作用的有效部位。 关键词:龙须藤;镇痛;抗炎;乙酸乙酯萃取物;正丁醇萃取物 Study on the anti鄄inflammatory and analgesic effects of Bauhinia championii Benth extract YIJingli,ZHANGJiajia,ZHOU Yisheng,WANG Song,ZHAOYongheng (School of Traditional ChineseMedicine,Guangdong Pharmaceutical College,Guangzhou510006,China) Abstract:Objective To research the anti鄄inflammatory and analgesic effects of the ethanol extract from Bauhinia championii Benth,and screen out effective fractions of anti鄄inflammatory and analgesic effects fromBauhinia championii Benth. Methods Two modelsthat hot plates andwrithing test causedby glacial acetic acid in micewereusedtoobservetheanti鄄inflammatory effect;themodelthatearswellingcausedby dimethyl benzene in mice was used to observe the analgesic effect. Results The ethanol extract from Bauhinia championii Benthhasgoodeffectofanti鄄inflammatoryandanalgesic. Ethylacetateextractandn鄄 butanol extract show significant effect of anti鄄inflammatory,and inhibit effusion of tissue fluid caused by inflammation. Conclusion Ethyl acetate extract and n鄄butanol extract may be the effective parts of Bauhinia championii Benth for the anti鄄inflammatory and analgesic effects. Key words:Bauhinia championii Benth;anti鄄inflammatory;analgesic;Ethyl acetate extract;n鄄butanol extract 摇 摇 龙须藤为豆科苏木亚科羊蹄甲属植物龙须藤 目前对龙须藤的药效基础研究还不够深入,其抗风 Bauhinia championii (Benth.) Benth. 的干燥藤茎。 湿性关节炎的有效成分不清,极大限制了该药材在 别名又称为:过岗圆龙、九龙藤、羊蹄藤、梅花入骨丹 临床上的应用。 本实验为考察龙须藤药材的镇痛抗 等,性味甘、微苦、温,具有祛风除湿、行气活血的功 炎作用,筛选出龙须藤的镇痛抗炎作用的有效部位, [1] 效