《计算系统生物学导论》系统生物学导论-2012-3.pptVIP

要点陈述 　研究背景 　研究内容概要 　总结和展望 芯片数据标准化 The source of noise Irregularities in the array surface Variations in the laboratory process Different scanner settings Different amounts of mRNA Different DNA strands have different hybridization properties Random noise 1. 图像分析 2. 扫描 3. DNA杂交过程 (温度、时间、混合均匀程度等) 4. 探针的标记 5. RNA的抽提 6. 加样 7. 其他 Data normalization supposed to adjust the global properties of measurements of individual samples so that they can be ‘‘more suitable compared’’ with a statistical benefit from removing large technical variations increasing the power of finding biological signa