板党对冈田酸致大鼠阿尔茨海默病抗氧化作用＊.PDFVIP

2008 9 24 9 　　Chi n J P ubl ic Health Sep 2008 Vol.24 No.9 1105 :1001-0580(2008)09-1105-02　　:Q 51;R 282.71　　:A 【】 ＊ 黄丽亚,张宏,余洁 　　　:　 (Alzheimer disease,AD)、 (tau )。　(Okadaic acid, OA ), C(V, C) , 、、、、、、(OD)、 (G H-PX)、(MDA )tau 。 　 OD(114.98±22.90)、 G H-PX(13.11±1.78) OD(159.94 ±14.67)、GPK-PK (12.25±1.47)(P0.05, P 0.001), MDA(5.38±2.76)、tau (174.97 ±12.89)MDA(4.81±1.54)、tau (148.61±10.77) (P0.001)。, OD、G H-PX、M DA tau , (750 mg)、 (500 mg)(P0.05), (250 mg)(P0.05)。　 OD、G H-PX 、MDA 、 tau 。 :;;OD;G H-PX;MDA;tau Anti-oxigenated effect of codonopsispilosula(Enshi)on Alzheimer disease of rat inducedby okadaic acid　HUAN GLi-ya, ZHAN GHong, Y UJie.Medical School of Hubei Institutef or Nationalities (Enshi 445000, hina) Abstract:Objective　To observe the effect of codonopsis pilosula (Enshi)on expression of oxygen free-radical and tau protein in gyrus hippocampi and cerebral cortex of rats with Alzheimer disease induced by okadaic acid.Methods　The rat model of Alzheimer disease induced by okadaic acid w as employed.Positive control and test group were injected with Vit.C. Codonopsis pilosula (Enshi)groups and control group s supreoxide dismutase (OD), glutathione peroxidase(G H-PX ), malondialdehyde(MDA)and tau protein in gyrus hippocampi and cerebral cortex were measured.Results　In contrast w ith control groups, concentrations of OD (114.98±22.90), G H-PX(13.11±1.78)and OD(159.94 ±14.67), G H-PX (12.25±1.47)in cerebral cortex and gyrus hippocampi of rats with Alzheimer disease w ere low er(P0.05,0.001).Con- centrations of MDA(5.38±2.76),Tau (174.97 ±12.89)and MDA (4.81±1.54), Tau(148.61±10.77)in cerebral cor- tex and gyrus hippocampi of model rats were higher than that of control group (P0.001).Concentrations of OD, G H- PX, MDA and tau protein showed statistically significant difference betwee