d-二聚体在颅内静脉窦血栓形成诊治中的研究进展 - 中国卒中杂志.pdf

860 Chin J Stroke, Oct 2014, Vol 9, No.10 ·综述· D-二聚体在颅内静脉窦血栓形成 诊治中的研究进展 陈丹莉，吐尔逊·沙比尔，张祥 作者单位 【摘要】 D-二聚体是交联纤维蛋白在纤溶酶作用下产生的一种特异性降解产物。既可反映凝血 830000 乌鲁木齐 酶的活性，又可反映纤溶酶的活性。近年来大量研究表明，D-二聚体在颅内静脉窦血栓形成中普遍 新疆医科大学第一附属 升高，有助于早期诊断颅内静脉窦血栓形成，因此D-二聚体异常升高提示颅内静脉窦血栓形成可能， 医院神经内科 通信作者 但D-二聚体正常能否除外颅内静脉窦血栓形成仍存在争议。本文就D-二聚体和颅内静脉窦血栓 吐尔逊·沙比尔 形成的关系，D-二聚体在颅内静脉窦血栓形成的早期诊断、治疗及预后判断中的临床意义做一综述， 163.com 以期指导临床。 【关键词】 颅内静脉窦血栓形成；D-二聚体；诊断 【DOI】 10.3969/j.issn.1673-5765.2014.10.010 Research Progress in the Diagnosis and Treatment of D-dimer in Cerebral Venous Sinus Thrombosis CHEN Dan-Li, TUERXUN Shabier , ZHANG Xiang. Department of Neurology, the First Affiliated Hospital of Xinjiang Medical University, Urumqi 830000, China Corresponding Author:TUERXUN Shabier, E-mail163.com 【 】 Abstract D-dimer is a specific crosslinked fibrin degradation product generated in the action of plasmin. It can not only reflect the activity of thrombin, but also plasmin activity. In recent years, numerous studies have demonstrated that D-dimer increased in the majority of patients with cerebral venous sinus thrombosis (CVST) and it is helpful in its early diagnosis. Abnormally elevated D-dimer may prompt CVST, but whether normal D-dimer can exclude CVST remains controversial. This paper describes the relationship between D-dimer and CVST, and discusses the clinical significance of D-dimer played in the early diagnosis of CVST, treatment and prognosis. 【 】