靶向振荡磁场发生器的研制.pdfVIP

第31卷第7期 舌 庆 大 学 学 报 Vo1．31 NO．7 2008年 7月 Journal ofChongqingUniversitY Ju1．2008 文章编号：1000 582X(2008)07—0749—05 靶向振荡磁场发生器的研制 付志红 ，赵俊丽 ，罗 聪。，谢品芳 (1．重庆大学 输配电装备及系统安全与新技术国家重点实验室，重庆400030； 2．重庆医科大学 附属第一医院，重庆 400016) 摘 要：针对药物靶向治疗中难以产生足够磁场强度和梯度的交流脉冲磁场问题，提出了采用 双极性脉冲电流产生靶向引导磁场的新思路，研常l了一种适用于磁性药物聚焦和控常1药物释放的 靶向振荡磁场发生器。其主电路拓扑利用负载能量回馈，减少电路损耗，提高电流幅值和电流脉冲 陡度，从而提高磁场强度和磁场强度变化率。该装置输出频率 0．125～32 Hz，磁感应强度达 1．3 T，正弦磁场、单极性和双极性脉冲磁场的磁性微粒聚焦效果和振荡效果的对比实验。证明双极 性陡脉冲强磁场更适用于靶向治疗。双极性脉冲强磁场中磁性微粒聚集速度快，聚焦效果好，振荡 现象明显。 关键词：双极性脉冲电流；靶向治疗；引导磁场；振荡磁场；磁聚焦 中图分类号：TM154 文献标志码：A Development of a targeting oscillating magnetic field generator FU Zhi—hong ，ZHAO Jun—li ，LUO Cong ，XIE Pin—fang (1．State Key I．aboratory of Power Transmission Equipment＆ System Security and New Technology， Chongqing University，Chongqing 400030，P．R．China：2．The First Affiliated Hospital， Chongqing University of Medical Sciences，Chongqing 40001 6，P．R．China) Abstract：Focusing on the key equipment of targeting therapy，a novel method of adopting bipolar pulse current to generate guiding magnetic field was proposed． A high targeting oscillating magnetic field generator also was developed．These innovations were used to control the focus and to release magnetic drugs to iu an effort to treat cancer．Based on the proposed transmission circuit，the load inductance energy feedback circuit reduces loss，improves the current amplitude and strengthens the magnetic field．Work frequency of the designed equipment is 0．125 Hz to 32 Hz．and the magnetic induction intensity reaches 1．3 T．Experimental results show that．compared to sinusoidal and unipolar pulse magnetic fields。the bipolar steep pulse magnetic field is more su