三七粉体物理特性及体外溶出行为的比较(jiang xi university of .pdfVIP

三七粉体物理特性及体外溶出行为的比较 陈绪龙，廖正根，祝婧云，赵国巍*，梁新丽，钟绍金，张南 （江西中医学院现代中药制剂教育部重点实验室，南昌，330004 ） 摘要：目的 比较三七细粉（D90为89.6 μm ）和3种粒径级别超微粉体（微粉Ⅰ、微粉Ⅱ、 微粉Ⅲ的D90分别为63.21、29.10 和9.17 μm ）物理特性和有效成份体外溶出行为的差异，为 三七超微粉体的粒径控制与应用提供试验依据。方法 通过测定三七细粉和3种粒径级别超微 粉体的粒径及分布、吸湿性、粉体的形貌结构等物理特性和体外溶出行为，研究三七粉体的 粒径对其物理特性和体外溶出行为的影响。结果 三七细粉与3种粒径级别超微粉体的吸湿曲 线相似。微粉Ⅰ有效成分的溶出速率和累积溶出量均高于其它3种粉体。结论 适度的微粉化 能促进三七有效成分的充分利用，超微粉碎技术应用于三七具有可行性和必要性。 关键词： 三七；超微粉体；物理特性；体外溶出 Comparison of physical characteristics and active ingredient dissolution behavior between fine powder and ultrafine powders of Panax notoginseng (Jiang Xi University of Traditional Chinese Medicine Key Laboratory of Mordern Preparation of TCM, Ministry of Education, Nanchang, 330004, China) CHEN Xu-long, LIAO Zhen-gen,ZHU Jing-yun, ZHAO Guo-wei*, LIANG Xin-li, ZHONG Shao-jin，Zhang-nan ABSTRACT:OBJECTIVE: It was Compared the differences about physical characteristics and active ingredients dissolution behavior between fine powder （D90:89.6 μm ）and 3 ultrafine powders (D90 :63.1, 29.10 and 9.17 μm)of Panax notoginseng to provide experimental evidence for the ultrafine powder application and the control of paticle size. METHOD: particle size and distribution, hygroscopicity, powder morphology of the physical properties and dissolution behavior was used to evaluate the impact of particle size on physical characteristics and dissolution of powders of Panax notoginseng. RESULTS: Fine powder and 3 ultrafine powders of Panax notoginseng hygroscopicity was similar to each other. The cumulative dissolution rate of the active ingredients of utrafine powder Ⅰwas significantly higher than the other powders. 基金项目:国家中医药管理局公益性行业科研专项(200807054);江西省对外科技合作项目(2008BB24800); 江西省教育厅青年科学基金项目(GJJ10214);十一五重大新药创制项目（2009ZX09310-005 作者简介: 陈绪龙（1984~），男，硕士研究生，从事中药新剂型与新技术的研究，电话：0791-711