茶多酚急性毒性试验研究 - by-healthcom.pdf

6 9 Vol. 6 No. 9 2015 9 Journal of Food Safety and Quality Sep. , 2015 * 袁根良 , 蒋 丽, 殷光玲 (, 510663) 摘 要: 目的 , 方法 6 , 1.002.154.6410.021.5 g/kg 20 mL/kg , 2 , 14 d结果 , (1.00 g/kg2.15 g/kg) 14 d , ; , , (P0.05) , (P0.05) 结论 , 关键词: ; ; Experimental study on acute toxicity of tea polyphenols * YUAN Gen-Liang , JIANG Li, YIN Guang-Ling (By-Health Co. , Ltd. , Guangzhou 510663, China) ABSTRACT: Objective To study the acute toxicity of tea polyphenols in order to provide a theoretical basis for the application in health food. Methods The rats were divided into 6 groups, i.e., the five groups fed with the intragastric dose of 1.00, 2.15, 4.64, 10.0, 21.5 g/kg respectively and the blank control group. The rats were given test solutions of different concentrations by the weight capacity of 20 mL/kg, twice a day for consecutive 14 days. Results Successional death occurred in rats fed with high doses of polyphenols. No obvious abnormalities were observed in rats of low dose groups (1.00 g/kg, 2.15 g/kg) after dissection at 14 d. There were no significant differences in the organ weight and the ratio of organ to body weight compared with the control group (P0.05). There was no statistical significance in the body weight in comparison of the rats in each dose group and the control group (P0.05). Conclusion Tea polyp