脂肪细胞对胰岛beta细胞功能的内分泌调节作用.pdfVIP

Acta Physiologica Sinica , June 25, 2007, 59 (3): 247-252 247 Brief Review Regulation of pancreatic β-cell function by adipocytes ZHAO Yu-Feng1,2, CHEN Chen1,* 1Endocrine Cell Biology, Prince Henry’s Institute of Medical Research, Melbourne, VIC 3168, Australia; 2Department of Physiology, the Fourth Military Medical University, Xi’an 710032, China Abstract: Adipokines, the bioactive factors derived mainly from adipocytes, regulate pancreatic β-cell function including insulin secretion, gene expression and apoptosis. In this review, we propose that adipokines influence β-cell function through three inter- dependent pathways. The first is through regulating lipid and glucose metabolism in β-cells. The second implicates the change of ion channel opening and closing in β-cells. The third pathway is via the modification of insulin sensitivity of β-cells. The endocrine function of adipocytes is dynamic, and the secretion of various adipokines changes under different metabolic conditions. During the progression from the normal state to obesity and to type 2 diabetes, adipokines contribute to the occurrence and development of β-cell dysfunction in type 2 diabetes. Key words: adipokines; insulin; β-cells; diabetes 脂肪细胞对胰岛β 细胞功能的内分泌调节作用 1,2 1,* 赵玉峰 ，陈 晨 1 2 亨利王子医学研究所内分泌细胞生物学研究室，墨尔本，维多利亚州3168 ，澳大利亚； 第四军医大学生理学教研室， 西安 710032 摘 要：脂肪因子包括脂肪细胞分泌的多种活性因子，它们通过内分泌方式调节胰岛β细胞的胰岛素分泌、基因表达以及细 胞凋亡等多方面的功能。本文提出脂肪因子影响胰岛β细胞功能主要通过三条相互联系的途径而实现。第一是调节β细胞内 葡萄糖和脂肪的代谢；第二是影响β细胞离子通道的活性；第三是改变β细胞本身的胰岛素敏感性。脂肪细胞的内分泌功能 是一个动态过程，在不同的代谢状态下，各脂肪因子的分泌发生不同变化。从正常代谢状态发展到肥胖以及2 型糖尿病的过 程中，脂肪因子参与了胰岛β细胞功能障碍的发生与发展。 关键词：脂肪因子；胰岛素；β 细胞；糖尿病 中图分类号：Q 4 5 The adipocyte is an endocrine cell that secretes many fac- nature of leptin characterises the adipocyte as an endo- tors and plays an important role in energy metab