化浊解毒汤治疗2型糖尿病合并高脂血症的临床疗效探究.pdfVIP

提 要 目的：观察化浊解毒汤治疗2 型糖尿病合并高脂血症的临床疗效，为中医中药预 防和治疗 2 型糖尿病合并高脂血症寻找可靠方法。 方法：将本研究纳入的 60 例 2 型糖尿病合并高脂血症患者，随机分为两组：治 疗组 30 例，对照组 30 例。在两组均坚持饮食及运动疗法基础上，对照组给予二甲双 胍、辛伐他汀，治疗组在对照组基础上加用化浊解毒汤，治疗 2 个月后，观察治疗前 后患者中医证候积分、血糖 （FPG 、2hPG ）、血脂 （TC、TG、LDL-C 、HDL-C ）、 HbA1c 、BMI 等指标的变化，并对上述结果进行统计学处理。 结果：经过2 个月治疗后，两组患者的血糖、血脂、中医证候积分、体重指数均 得到改善，两组间比较有差异（P ＜0.05 ），治疗组优于对照组；两组中医证候疗效比 较有差异（P ＜0.05 ），治疗组优于对照组；两组在改善患者糖化血红蛋白方面无差异 （P ＞0.05 ）。安全性评价：两组均未出现毒副作用。 结论：化浊解毒汤对 2 型糖尿病合并高脂血症患者的血糖、血脂水平有改善作用， 在改善中医证候方面优于对照组，初步认为化浊解毒汤是治疗 2 型糖尿病合并高脂血 症的有效方剂。 关键词 2 型糖尿病；高脂血症；化浊解毒汤；临床观察 The Clinical Research of HuazhuoJiedu Decoction in the Treatment of Type 2 Diabetes Mellitus Combined With Hyperlipemia Speciality:Internal medicine of Traditional Chinese Medicine Author:Liu Yun xia Tutor:Professor Zhao Quan lin Abstract Objective: To observe the clinical efficacy of HuazhuoJiedu decoction in treating type 2 diabetes mellitus combined with hyperlipemia. in order to find the reliable way to discuss Chinese medicine in the prevention and treatment for type 2 diabetes mellitus combined with hyperlipemia. Methods: The 60 patients with type 2 diabetes mellitus combined with hyperlipemia ， who had been chosen into this clinical research,were randomly divided into two groups, the treatment group and the control group.Each group had 30 cases.On the base of the same diabetes diet and exercise therapy，the patients of control group were treated with metformin and simvastatin,based on the control group,the patients of the treatment group were added to HuaZhuojiedu decoction. With a period of 2 months’ treatment,we could observe the patients’ change on the TCM syndrome, blood glucose （FPG 、2hPG ）、blood lipid （TC、TG、LDL-C 、HDL-C ）、HbA1c 、BMI and other indicators ，and analyze the